[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. STRAIN=R04; Asano Y.; "Phenylalanine dehydrogenase."; Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: L-phenylalanine + H₂O + NAD⁺ = phenylpyruvate + NH₃ + NADH.
PATHWAY: Amino-acid biosynthesis; L-phenylalanine biosynthesis; L-phenylalanine from phenylpyruvate (PDH route): step 1/1 .
SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

Copyright

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Cross-references

Sequence databases

EMBL

AB001031; BAA19221.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

HSSP

Q59771; 1C1D. [HSSP ENTRY / PDB]

ModBase

P97014.

Ontologies

GO:0050175;	Molecular function: phenylalanine dehydrogenase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR016211; Glu/Phe/Leu/Val_DHase_bac/arc.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000188; Phe_leu_dh; 1.

PRINTS

PR00082; GLFDHDRGNASE.

PROSITE

PS00074; GLFV_DEHYDROGENASE; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 379`	`379`	`Phenylalanine dehydrogenase.`	`PRO_0000182808`
`NP_BIND`	`192 198`	`7`	`NAD (Potential).`
`ACT_SITE`	`92 92`		`By similarity.`

Sequence information

Length: 379 AA [This is the length of the unprocessed precursor]

Molecular weight: 41329 Da [This is the MW of the unprocessed precursor]

CRC64: 3764391A07B4C0A8 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MILVTLEQTL QDDKASVLDK MVEHEQILFC HDKATGLQAI IAVHDTTMGP ALGGCRMAPY 

        70         80         90        100        110        120 
KTMDLALKDV LRLSKGMTYK CAAADVDFGG GKSVIIGDPL KDKTPEKFRA FGQFIESLNG 

       130        140        150        160        170        180 
RFYTGTDMGT TLEDFVHAMK ETNYIVGKPV EYGGGGDSSI PTALGVFYGI KATNQNLFGD 

       190        200        210        220        230        240 
DKVEGRKYSI QGLGKVGYKV AEHIINEGGN VIVTDINEQA IADIQKLGGS AVRVVSSEEI 

       250        260        270        280        290        300 
YSQQADVFVP CAFGGVINDD TLKVLKVRGI SGSANNQLAE SRHGELLREK GILYAPDYIV 

       310        320        330        340        350        360 
NGGGLIQVAD ELYGTNPARV LAKTENIYTS LLEVFHQAEQ DHMTTATAAD RMCEKRIADA 

       370 
KNRNSFFTQS NRPKWNFHQ

P97014 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools