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UniProtKB/Swiss-Prot entry Q00667


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_EMENI
Primary accession number Q00667
Secondary accession number Q5BC33
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1996 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 51)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisic acid oxidase
Homogentisate oxygenase
Homogentisicase
Gene name
Name: hmgA
ORFNames: AN1897
From
Emericella nidulans (Aspergillus nidulans) [TaxID: 162425] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; Emericella.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=biA1;
DOI=10.1074/jbc.270.36.21199; PubMed=7673153 [NCBI, ExPASy, EBI, Israel, Japan]
Fernandez-Canon J.M., Penalva M.A.;
"Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues.";
J. Biol. Chem. 270:21199-21205(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=FGSC 4;
DOI=10.1038/nature04341; PubMed=16372000 [NCBI, ExPASy, EBI, Israel, Japan]
Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S., Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V., Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S., Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H., Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K., Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R., Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C., Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L., Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
"Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.";
Nature 438:1105-1115(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U30797; AAC49071.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AJ001836; CAA05042.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AACD01000029; EAA65062.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A57435; A57435.
RefSeq XP_659501.1; -.
3D structure databases
HSSP Q93099; 1EYB. [HSSP ENTRY / PDB]
ModBase Q00667.
Enzyme and pathway databases
BioCyc MetaCyc:MON-12040; -.
Family and domain databases
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q00667.
Genome annotation databases
GeneID 2874820; -.
KEGG ani:AN1897.2; -.
Other
ProtoNet Q00667.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   448  448     Homogentisate 1,2-dioxygenase. PRO_0000220245
METAL   340   340        Iron (By similarity). 
METAL   346   346        Iron (By similarity). 
METAL   377   377        Iron (By similarity). 
Sequence information
Length: 448 AA [This is the length of the unprocessed precursor] Molecular weight: 50168 Da [This is the MW of the unprocessed precursor] CRC64: 4AE6414823A04C0D [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPVTEFSFKD PYTYQNGFDS YHESEAIEGA LPVGHNSPQK APYGLYAEKL SGTAFTAPRH 

        70         80         90        100        110        120 
ENKQTWVYRI LPAAAHENFV EEDASSYHTL SDAKKLQHIP NQLRWDPFDL DETVDWVHGL 

       130        140        150        160        170        180 
HLVAGSGDPT VKQGLGILLY AAGKDMGKEA FYSADGDFLI VAQHGVLDIQ TELGRLLVRP 

       190        200        210        220        230        240 
NEICVIPRGV RYRVTLPDGP VRGYICELYQ GHYQLPELGP IGSNGLANAR DFQAPVAAFD 

       250        260        270        280        290        300 
DEEGPTEYRL YSKFNNHLFS ARQDHTPFDI VAWHGNYYPY KYDLGRFNTM GSVSFDHPDP 

       310        320        330        340        350        360 
SIYTVLTGPS DHVGTAIADF VIFPPRWLVA EKTFRPPWYH RNTMSEFMGL ITGNYDAKTG 

       370        380        390        400        410        420 
GGFQPAGASL HNIMSAHGPD MHAFEGASNA DLKPTKIGDG SMAFMFESSL MVGVSEWGLK 

       430        440 
TCQKVQEEYN EHSWQPLKRH FKDPRKAQ 

Q00667 in FASTA format

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