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UniProtKB/Swiss-Prot entry Q00673


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name NDUS3_CANMA
Primary accession number Q00673
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 1, 1993 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 51)
Name and origin of the protein
Protein name Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial [Precursor]
Synonyms EC 1.6.5.3
EC 1.6.99.3
Complex I-30kD
CI-31kD
Alkane-inducible protein 1
Gene name
Name: ALI1
From
Candida maltosa (Yeast) [TaxID: 5479] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; mitosporic Saccharomycetales; Candida.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1016/0378-1119(91)90566-T; PubMed=1937042 [NCBI, ExPASy, EBI, Israel, Japan]
Hwang C.W., Yano K., Takagi M.;
"Sequences of two tandem genes regulated by carbon sources, one being essential for n-alkane assimilation in Candida maltosa.";
Gene 106:61-69(1991).
[2]
POSSIBLE FUNCTION.
Bairoch A.;
Unpublished observations (OCT-1993).
Comments
  • FUNCTION: Essential for N-alkane assimilation.
  • FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
  • CATALYTIC ACTIVITY: NADH + ubiquinone = NAD+ + ubiquinol.
  • CATALYTIC ACTIVITY: NADH + acceptor = NAD+ + reduced acceptor.
  • SUBUNIT: Complex I is composed of about 30 different subunits. This is a component of the iron-sulfur protein fraction.
  • SUBCELLULAR LOCATION: Mitochondrion inner membrane.
  • SIMILARITY: Belongs to the complex I 30 kDa subunit family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M61102; AAA34360.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR JT0591; JT0591.
3D structure databases
ModBase Q00673.
Family and domain databases
InterPro IPR010218; NADH_DH_csu.
IPR001268; NADH_DHase_Ub_30kDa_su.
Graphical view of domain structure.
Pfam PF00329; Complex1_30kDa; 1.
Pfam graphical view of domain structure.
ProDom PD001581; Complex1_30K; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01961; NuoC_fam; 1.
PROSITE PS00542; COMPLEX1_30K; 1.
BLOCKS Q00673.
Other
ProtoNet Q00673.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; Transit peptide; Transport; Ubiquinone.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
TRANSIT   1     ?        Mitochondrion (Potential). 
CHAIN   ?   276        Probable NADH-ubiquinone oxidoreductase 30.4 kDa subunit, mitochondrial. PRO_0000020001
Sequence information
Length: 276 AA [This is the length of the unprocessed precursor] Molecular weight: 32158 Da [This is the MW of the unprocessed precursor] CRC64: 1CA55A6CF1459A72 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MISRTLLKRT VPASRLLRSF TTSNVRLSAH EEDLVNVNNL PRPKPTENYV PLINPTEKYK 

        70         80         90        100        110        120 
VQIEELHKFG TYIMSCLPKY IQQFSVWKDE LTIYVAPSAI RPVMSYLKNH TSCQFKAVMD 

       130        140        150        160        170        180 
ITAADYPSRT NRFDVVYNLL SDRHNSRIRV KTYANETSPV PSVTPLFNGA NWYERETYDL 

       190        200        210        220        230        240 
FGVFFVGHPD LRRIMTDYGF EGHPLRKDFP TTGYTEVRYD EEKKRVIYEP LELTQAWRNF 

       250        260        270 
TVGSSVWEPV GEGKDFTPES FKLPTPQPEP EQEEKK 

Q00673 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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