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UniProtKB/Swiss-Prot entry Q03163

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH_CATRO
Primary accession number Q03163
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on February 1, 1994 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 61)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Synonyms HMG-CoA reductase
EC 1.1.1.34
Gene name
Name: HMGR
From
Catharanthus roseus (Madagascar periwinkle) (Vinca rosea) [TaxID: 4058] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons; asterids; lamiids; Gentianales; Apocynaceae; Rauvolfioideae; Vinceae; Catharanthus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=cv. Little Delicata;
TISSUE=Seedling;
PubMed=16653173 [NCBI, ExPASy, EBI, Israel, Japan]
Maldenado-Mendoza I.E., Burnett R.J., Nessler C.L.;
"Nucleotide sequence of a cDNA encoding 3-hydroxy-3-methylglutaryl-CoA reductase from Catharanthus roseus.";
Plant Physiol. 100:1613-1614(1992).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M96068; AAA33108.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T09967; T09967.
3D structure databases
HSSP P04035; 1HWI. [HSSP ENTRY / PDB]
ModBase Q03163.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
Gene3D G3DSA:3.90.770.10; HMG-CoA_red; 1.
PANTHER PTHR10572; HMG-CoA_red; 1.
Pfam PF00368; HMG-CoA_red; 1.
Pfam graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q03163.
Other
ProtoNet Q03163.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   601  601     3-hydroxy-3-methylglutaryl-coenzyme A reductase. PRO_0000114437
TRANSMEM   36    58  23     Potential. 
TRANSMEM   86   106  21     Potential. 
REGION   107   179  73     Linker (By similarity). 
REGION   180   601  422     Catalytic (By similarity). 
ACT_SITE   273   273        Charge relay system (By similarity). 
ACT_SITE   405   405        Charge relay system (By similarity). 
ACT_SITE   481   481        Charge relay system (By similarity). 
ACT_SITE   579   579        Proton donor (By similarity). 
CARBOHYD   337   337        N-linked (GlcNAc...) (Potential). 
CARBOHYD   583   583        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 601 AA [This is the length of the unprocessed precursor] Molecular weight: 64107 Da [This is the MW of the unprocessed precursor] CRC64: D49D00D4F5DB9113 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDSRRRSPTV TAKAAAGELP LAPHEGQNQQ PSIPRSSDVL PLPLYLANGV FFTLFFSVMY 

        70         80         90        100        110        120 
FLLTRWREKI RNATPLHVVT LSELAALASL IASVIYLVSF FGLDFVQSLI YKPNNEGWEI 

       130        140        150        160        170        180 
EEEILMVEDS RNGTNCTTLG CAVPPPSVPK IAPVVPQQPS KMVIIEKPAP LITPQNSEED 

       190        200        210        220        230        240 
EDIIKAVVAG KIPSYSLESK LGDCKRAAGI RREALQRITG KSLEGLPLEG FDYASILGQC 

       250        260        270        280        290        300 
CEMPVGYVQL PVGIAGPLLL DGREYMLPMA TTEGCLVAST NRGCKAILAS GGANSVLLRD 

       310        320        330        340        350        360 
GMTRAPVVRF GTAKRAAELK FYMEDTQNFE TISVVFNKSS RFAKLQSVQC AIAGKNLYIR 

       370        380        390        400        410        420 
FSCSTGDAMG MNMVSKGVQN VLEFLQTDYP DMDVLGISGN FCADKKPAAV NWIEGRGKSV 

       430        440        450        460        470        480 
VCEAIIKEEI VKTVLKTEVA ALIELNMVKN LAGSAIAGAL GGFNAHASNI VSAIFIATGQ 

       490        500        510        520        530        540 
DPAQNVESSQ CITMMEAVND GKDLHISVTM PSIEVGTVGG GTQLASQSAC LNLLGVKGAS 

       550        560        570        580        590        600 
KDSPGANSRL LATIVAGSVL AGELSLMSAI SAGQLVRSHM KYNRSSKDIT NIASSQLESD 


S
Q03163 in FASTA format

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