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UniProtKB/Swiss-Prot entry Q03578

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHE2_PORGI
Primary accession number Q03578
Secondary accession numbers None
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on October 3, 2003 (Sequence version 2)
Annotations were last modified on    September 2, 2008 (Entry version 60)
Name and origin of the protein
Protein name NAD-specific glutamate dehydrogenase
Synonyms NAD-GDH
EC 1.4.1.2
Surface-associated protein PGAG1
Gene name
Name: gdh
OrderedLocusNames: PG_1232
From
Porphyromonas gingivalis (Bacteroides gingivalis) [TaxID: 837] [HAMAP proteome]
Taxonomy Bacteria; Bacteroidetes; Bacteroidetes (class); Bacteroidales; Porphyromonadaceae; Porphyromonas.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC 33277 / DSM 20709 / JCM 12257 / NCTC 11834 / 2561;
PubMed=8132343 [NCBI, ExPASy, EBI, Israel, Japan]
Joe A., Murray C.S., McBride B.C.;
"Nucleotide sequence of a Porphyromonas gingivalis gene encoding a surface-associated glutamate dehydrogenase and construction of a glutamate dehydrogenase-deficient isogenic mutant.";
Infect. Immun. 62:1358-1368(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-308 / W83;
DOI=10.1128/JB.185.18.5591-5601.2003; PubMed=12949112 [NCBI, ExPASy, EBI, Israel, Japan]
Nelson K.E., Fleischmann R.D., DeBoy R.T., Paulsen I.T., Fouts D.E., Eisen J.A., Daugherty S.C., Dodson R.J., Durkin A.S., Gwinn M.L., Haft D.H., Kolonay J.F., Nelson W.C., Mason T.M., Tallon L., Gray J., Granger D., Tettelin H., Dong H., Galvin J.L., Duncan M.J., Dewhirst F.E., Fraser C.M.;
"Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83.";
J. Bacteriol. 185:5591-5601(2003).
[3]
 PROTEIN SEQUENCE OF 1-29.
PubMed=8392971 [NCBI, ExPASy, EBI, Israel, Japan]
Joe A., Yamamoto A., McBride B.C.;
"Characterization of recombinant and native forms of a cell surface antigen of Porphyromonas (Bacteroides) gingivalis.";
Infect. Immun. 61:3294-3303(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L07290; AAA50985.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE015924; AAQ66318.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_905419.1; -.
3D structure databases
HSSP P24295; 1AUP. [HSSP ENTRY / PDB]
ModBase Q03578.
Enzyme and pathway databases
BioCyc PGIN242619:PG1232-MON; -.
Ontologies
GO
GO:0009986; Cellular component: cell surface (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR006095; Glu/Leu/Phe/Val_DHase.
IPR006096; Glu/Leu/Phe/Val_DHase_C.
IPR006097; Glu/Leu/Phe/Val_DHase_dimer.
IPR014362; Glu_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR11606:SF2; GLFV_DH; 1.
Pfam PF00208; ELFV_dehydrog; 1.
PF02812; ELFV_dehydrog_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000185; Glu_DH; 1.
PRINTS PR00082; GLFDHDRGNASE.
PROSITE PS00074; GLFV_DEHYDROGENASE; 1.
BLOCKS Q03578.
Genome annotation databases
GeneID 2553197; -.
GenomeReviews AE015924_GR; PG_1232.
KEGG pgi:PG1232; -.
NMPDR fig|242619.1.peg.1060; -.
TIGR PG_1232; -.
Phylogenomic databases
HOGENOM Q03578; -.
Other
ProtoNet Q03578.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   445  445     NAD-specific glutamate dehydrogenase. PRO_0000182740
ACT_SITE   124   124        By similarity. 
CONFLICT   258   258        S -> Y (in Ref. 1; AAA50985). 
Sequence information
Length: 445 AA [This is the length of the unprocessed precursor] Molecular weight: 49199 Da [This is the MW of the unprocessed precursor] CRC64: 7436A9C2E01C503D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKTQEIMTML EAKHPGESEF LQAVKEVLLS VEEVYNQHPE FEKNGIIERI VEPDRVFTFR 

        70         80         90        100        110        120 
VPWVDDQGKV QVNIGYRVQF NNAIGPYKGG IRFHPSVNLS ILKFLGFEQM FKNALTTLPM 

       130        140        150        160        170        180 
GGGKGGADFS PKGKSEAEIM RFCQSFMTEL WRNIGPDTDI PAGDIGVGGR EVGYMFGMYK 

       190        200        210        220        230        240 
KLAREHTGTL TGKGFEFGGS RLRPESTGFG AVYFVQNMCK QNGVDYKGKT LAISGFGNVA 

       250        260        270        280        290        300 
WGVAQKATEL GIKVVTISGP DGYVYDPDGI NTPEKFRCML DLRDSGNDVV SDYVKRFPNA 

       310        320        330        340        350        360 
QFFPGKKPWE QKVDFAMPCA TQNEMNLEDA KTLHKNGVTL VAETSNMGCT AEASEYYVAN 

       370        380        390        400        410        420 
KMLFAPGKAV NAGGVSCSGL EMTQNAMHLV WTNEEVDKWL HQIMQDIHEQ CVTYGKDGNY 

       430        440 
IDYVKGANIA GFMKVAKAMV AQGVC
Q03578 in FASTA format

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