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UniProtKB/Swiss-Prot entry Q03AR1


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_LACC3
Primary accession number Q03AR1
Secondary accession numbers None
Integrated into Swiss-Prot on June 26, 2007
Sequence was last modified on November 14, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 14)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: LSEI_0911
From
Lactobacillus casei (strain ATCC 334) [TaxID: 321967] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0607117103; PubMed=17030793 [NCBI, ExPASy, EBI, Israel, Japan]
Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
"Comparative genomics of the lactic acid bacteria.";
Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000423; ABJ69711.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_806153.1; -.
3D structure databases
ModBase Q03AR1.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS Q03AR1.
Genome annotation databases
GeneID 4419308; -.
GenomeReviews CP000423_GR; LSEI_0911.
KEGG lca:LSEI_0911; -.
CMR Q03AR1; LSEI_0911.
Other
ProtoNet Q03AR1.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   329  329     GMP reductase. PRO_0000292051
NP_BIND   207   230  24     NADP (Potential). 
ACT_SITE   178   178        Thioimidate intermediate (By similarity). 
Sequence information
Length: 329 AA [This is the length of the unprocessed precursor] Molecular weight: 36504 Da [This is the MW of the unprocessed precursor] CRC64: 952A6568ED4643C8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNNGMQIFDY EDIQMIPNKC VVQSRKEVDT SVKFGPHTFK IPVVPANMQT IIDEPLAIWL 

        70         80         90        100        110        120 
AEHDYFYIMH RFQPERRMDF VRDMKKRGLI ASISVGVKDD EFDFIEALAA NELTPDYITI 

       130        140        150        160        170        180 
DIAHGYAQVV IDMIQHIKHY LPNAFVIAGN VGTPEAVREL ENAGADATKV GIGPGKVCIT 

       190        200        210        220        230        240 
KLKTGFGTGG WQLAAVRWCA KAARKPIIAD GGIRNNGDIA KSIRFGATMC MIGSLFAGHE 

       250        260        270        280        290        300 
ETPGKHVNID GKEYQEYYGS ASEYQKGTHH NVEGKKILLP VKGKIGDTLK EMQEDLQSAV 

       310        320 
SYAGGRDLES LTKVDYVIVK NSIFNGDQY 

Q03AR1 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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