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UniProtKB/Swiss-Prot entry Q04499


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PROD_DROME
Primary accession number Q04499
Secondary accession numbers O61349 Q8IQ45 Q8IQ46 Q8T0C7 Q9VRH7 Q9VRH8 Q9VRH9 Q9VRI2
Integrated into Swiss-Prot on October 1, 1993
Sequence was last modified on August 30, 2005 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 62)
Name and origin of the protein
Protein name Proline oxidase, mitochondrial [Precursor]
Synonyms EC 1.5.99.8
Proline dehydrogenase
Protein sluggish-A
Gene name
Name: slgA
Synonyms: slg
ORFNames: CG1417
From
Drosophila melanogaster (Fruit fly) [TaxID: 7227] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
STRAIN=Canton-S;
PubMed=8096642 [NCBI, ExPASy, EBI, Israel, Japan]
Hayward D.C., Delaney S.J., Campbell H.D., Ghysen A., Benzer S., Kasprzak A.B., Cotsell J.N., Young I.G., Miklos G.L.G.;
"The sluggish-A gene of Drosophila melanogaster is expressed in the nervous system and encodes proline oxidase, a mitochondrial enzyme involved in glutamate biosynthesis.";
Proc. Natl. Acad. Sci. U.S.A. 90:2979-2983(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM A).
STRAIN=Canton-S;
DOI=10.1073/pnas.95.7.3731; PubMed=9520435 [NCBI, ExPASy, EBI, Israel, Japan]
Maleszka R., de Couet H.G., Miklos G.L.G.;
"Data transferability from model organisms to human beings: insights from the functional genomics of the flightless region of Drosophila.";
Proc. Natl. Acad. Sci. U.S.A. 95:3731-3736(1998).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley;
DOI=10.1126/science.287.5461.2185; PubMed=10731132 [NCBI, ExPASy, EBI, Israel, Japan]
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[4]
GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
PubMed=12537572 [NCBI, ExPASy, EBI, Israel, Japan]
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
STRAIN=Berkeley;
TISSUE=Embryo;
PubMed=12537569 [NCBI, ExPASy, EBI, Israel, Japan]
Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E.;
"A Drosophila full-length cDNA resource.";
Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L07330; AAA02748.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF017777; AAC28410.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAF50814.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAF50819.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAF50820.2; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAF50821.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AE014298; AAF50822.3; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY069407; AAL39552.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A47302; A47302.
RefSeq NP_523433.2; -.
NP_728422.1; -.
NP_728423.1; -.
NP_728424.1; -.
NP_728425.1; -.
UniGene Dm.6612
3D structure databases
ModBase Q04499.
Organism-specific databases
FlyBase FBgn0003423; slgA.
Gene expression databases
ArrayExpress Q04499; -.
GermOnline CG1417; Drosophila melanogaster.
Ontologies
GO
GO:0042331; Biological process: phototaxis (inferred from mutant phenotype from FlyBase).
QuickGo view.
Family and domain databases
InterPro IPR002872; Proline_DHase.
IPR015659; Proline_oxidase.
Graphical view of domain structure.
PANTHER PTHR13914; Proline_oxidase; 1.
Pfam PF01619; Pro_dh; 1.
Pfam graphical view of domain structure.
BLOCKS Q04499.
Genome annotation databases
Ensembl CG1417; Drosophila melanogaster. [Contig view]
GeneID 33117; -.
KEGG dme:Dmel_CG1417; -.
Other
ProtoNet Q04499.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Complete proteome; FAD; Flavoprotein; Mitochondrion; Oxidoreductase; Proline metabolism; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    30  30     Mitochondrion (Potential). 
CHAIN   31   681  651     Proline oxidase, mitochondrial. PRO_0000025803
VAR_SEQ   1   325        Missing (in isoform C). VSP_015400
VAR_SEQ   158   192        LARNLLGQKLFVLLMKSSFYGHFVAGENRHTIVPA -> WSKNVLGQRLFTLLMKATFYGHFVAGEDQIKIIPT (in isoform A and isoform E). VSP_015401
VAR_SEQ   285   296        Missing (in isoform A and isoform B). VSP_015402
CONFLICT   42    42        S -> N (in Ref. 1; AAA02748). 
CONFLICT   147   147        K -> N (in Ref. 1; AAA02748). 
CONFLICT   149   149        V -> F (in Ref. 2; AAC28410). 
CONFLICT   285   296        Missing (in Ref. 1; AAA02748/AAC28410/AAF50820). 
Sequence information
Length: 681 AA [This is the length of the unprocessed precursor] Molecular weight: 77153 Da [This is the MW of the unprocessed precursor] CRC64: 2AB69ABB67D83FF8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MALLRSLSAQ RTAISLVYGR NSSKSSNSVA VAACRSFHQR GSGSTSIAGE GAASESTRGV 

        70         80         90        100        110        120 
NGARFLHSGD RPLQASTLVQ PEVVSSETVK RSMKQESSQE KNPSPAGSPQ RDPLDVSFND 

       130        140        150        160        170        180 
PIAAFKSKTT GELIRAYLVY MICSSEKLVE HNMTLMKLAR NLLGQKLFVL LMKSSFYGHF 

       190        200        210        220        230        240 
VAGENRHTIV PALERLRSFG VKPILDYSVE EDITQEEAEK REVESSVSSA GDKKEEGSMP 

       250        260        270        280        290        300 
QYHVDKSFAD RRYKVSSART YFYLNEATCE RNMEIFIKCL EAVSDDDRKA PRAVATGATF 

       310        320        330        340        350        360 
GTGITAIKLT ALGRPQLLLQ LSEVIMRTRK YMEDMVGGQG NVLTHHKTIK DLEKYYATLG 

       370        380        390        400        410        420 
DNKDVKEFLN NVTSDKEGIL HLFPWSGIVD EDSQLSDTFR VPDPQTGQMR RLISQIPPKE 

       430        440        450        460        470        480 
EEMFRNMIRR LNTIVKAAAD LDVRIMVDAE QTYFQPAISR ITLEMMRKYN KDKAIVFNTY 

       490        500        510        520        530        540 
QCYLRETFRE VNTDLEQAKR QNFYFGAKLV RGAYMDQERD RAKSLGYPDP VNPTFEATTD 

       550        560        570        580        590        600 
MYHRTLSECL RRIKLMKDCD DDARKIGIMV ASHNEDTVRF AIQQMKEIGI SPEDKVICFG 

       610        620        630        640        650        660 
QLLGMCDYIT FPLGQAGYSA YKYIPYGPVE EVLPYLSRRA QENKGVLKKI KKEKRLLLSE 

       670        680 
IRRRLMRGQL FYKPKGNYVP I 

Q04499 in FASTA format

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