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UniProtKB/Swiss-Prot entry Q045S8


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_LACGA
Primary accession number Q045S8
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on November 14, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 16)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: LGAS_0389
From
Lactobacillus gasseri (strain ATCC 33323 / DSM 20243) [TaxID: 324831] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0607117103; PubMed=17030793 [NCBI, ExPASy, EBI, Israel, Japan]
Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
"Comparative genomics of the lactic acid bacteria.";
Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000413; ABJ59794.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_814232.1; -.
3D structure databases
ModBase Q045S8.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS Q045S8.
Genome annotation databases
GeneID 4440320; -.
GenomeReviews CP000413_GR; LGAS_0389.
KEGG lga:LGAS_0389; -.
NMPDR fig|1596.1.peg.1138; -.
Phylogenomic databases
HOGENOM Q045S8; -.
Genome annotation databases
CMR Q045S8; LGAS_0389.
Other
ProtoNet Q045S8.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   330  330     GMP reductase. PRO_0000294275
NP_BIND   209   232  24     NADP (Potential). 
ACT_SITE   180   180        Thioimidate intermediate (By similarity). 
Sequence information
Length: 330 AA [This is the length of the unprocessed precursor] Molecular weight: 36644 Da [This is the MW of the unprocessed precursor] CRC64: C20266C30D19BDDE [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSNYFSMEAF DYDDIQLVPN KCIIKSRKEA DTSVKFGSRT FKIPVVPANM ESVIDDDLAI 

        70         80         90        100        110        120 
WLAENGYYYV MHRFHPEKRA NFIKMMHDKG LFASISVGIK DSEYDFIDYL AKEKIIPEYI 

       130        140        150        160        170        180 
TIDVAHGHSD YVIKMIKYIK DKLPDTFLTA GNIATPEAVR ELENAGADAT KVGVGPGRAC 

       190        200        210        220        230        240 
ITKLKTGFGT GGWQLAALRM CSKAARKPLI ADGGIRHNGD IAKSVRFGAS MVMIGSLFAG 

       250        260        270        280        290        300 
HEESPGNLIT IDGKRYKQYW GSASEVQKGA YRNVEGKQML VPYRGSIKDT LREMQEDLQS 

       310        320        330 
SISYAGGKDL SAIRVVDYVI VKSSIFDGDK 

Q045S8 in FASTA format

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