[1]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. PubMed=1336034 [NCBI, ExPASy, EBI, Israel, Japan] Morris S.L., Nair J., Rouse D.A.; "The catalase-peroxidase of Mycobacterium intracellulare: nucleotide sequence analysis and expression in Escherichia coli."; J. Gen. Microbiol. 138:2363-2370(1992).

Comments

FUNCTION: Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. May play a role in the intracellular survival of mycobacteria.
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
CATALYTIC ACTIVITY: Donor + H₂O₂ = oxidized donor + 2 H₂O.
COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group per dimer (By similarity).
SUBUNIT: Homodimer or homotetramer (By similarity).
PTM: The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme (By similarity).
SIMILARITY: Belongs to the peroxidase family. Peroxidase/catalase subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

M86741; AAA25360.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

A47685; A47685.

3D structure databases

HSSP

Q939D2; 1MWV. [HSSP ENTRY / PDB]

ModBase

Q04657.

Protein family/group databases

PeroxiBase

2433; MinCP01.

Family and domain databases

InterPro

IPR000763; Catalase_proxase.
IPR002016; Haem_peroxidase_pln/fun/bac.
Graphical view of domain structure.

Pfam

PF00141; peroxidase; 2.
Pfam graphical view of domain structure.

PRINTS

PR00460; BPEROXIDASE.
PR00458; PEROXIDASE.

TIGRFAMs

TIGR00198; cat_per_HPI; 1.

PROSITE

PS00435; PEROXIDASE_1; 1.
PS00436; PEROXIDASE_2; 1.
PS50873; PEROXIDASE_4; 1.
PROSITE graphical view of domain structure (profiles).

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Hydrogen peroxide; Iron; Metal-binding; Oxidoreductase; Peroxidase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 746`	`746`	`Peroxidase/catalase.`	`PRO_0000055570`
`ACT_SITE`	`114 114`		`Proton acceptor (By similarity).`
`METAL`	`277 277`		`Iron (heme axial ligand) (By similarity).`
`SITE`	`110 110`	`1`	`Transition state stabilizer (By similarity).`
`CROSSLNK`	`113 236`		`Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-262) (By similarity).`
`CROSSLNK`	`236 262`		`Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-113) (By similarity).`

Sequence information

Length: 746 AA [This is the length of the unprocessed precursor]

Molecular weight: 81418 Da [This is the MW of the unprocessed precursor]

CRC64: 15F35F7F5028F2B2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSSDTSSSRP PQPDSGTASK SESENPAIPS PKPKAHAPLT NRDWWPDQVD VSSLHPHSPL 

        70         80         90        100        110        120 
SNPLGDDFDY AAEFAKLDVE ALKADMISLM TTSQDWWPAD YGHYGGLFIR MSWHAAGTYR 

       130        140        150        160        170        180 
IHDGRGGAGQ GMQRFAPLNS WPDNASLDKA RRLLWPIKKK YGNKISWADL ITYAGNVALE 

       190        200        210        220        230        240 
SMGFKTFGFG FGREDVWEPE EILWGEEEEW LGTDKRYSGE RELAQPYGAT TMGLIYVNPE 

       250        260        270        280        290        300 
GPEGKPDPIA AAIDIRETFG RMAMNDEETA ALIVGGHSFG KTHGAGDADL VGPEPEAAPI 

       310        320        330        340        350        360 
EQQGLGWKSS YGTGSGKDAI TSGLEVVWTP TPTKWDNSFL ETLYGYEWEL TKSPAGAWQF 

       370        380        390        400        410        420 
TAKDGAGAGT IPDPFGGAGR APTMLVTDIS LRESPIYADI TRRWLDHPEE LADAFAKAWY 

       430        440        450        460        470        480 
KLLHRDMGPI SRYLGPWVAE PQLWQDPVPA VDHELVDDND VAALKKKVLD SGLSIPQLVK 

       490        500        510        520        530        540 
TAWSAAASYR NTDKRGGANG GRLRLQPQRS WEVNEPSELD KVLPVLEKIQ QDFNASASGG 

       550        560        570        580        590        600 
KKISLADLIV LAGSAAVEKA AKDAGYEISV HFAPGRTDAS QESTDVESFA VLEPRADGFR 

       610        620        630        640        650        660 
NYIRPGEKAP LEQLLIERAY LLGVTGPEMT VLVGGLRALG ANHGSSKHGV FTDRPGALTN 

       670        680        690        700        710        720 
DFFVNLLDMG TEWKASETAE NVYEGRDRAS GALKWTATAN DLVFGSNSVL RGLVEVYAQD 

       730        740 
DAHGKFVEDF VAAWVKVMNS DRFDLK

Q04657 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools