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UniProtKB/Swiss-Prot entry Q04CB0


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GUAC_LACDB
Primary accession number Q04CB0
Secondary accession numbers None
Integrated into Swiss-Prot on July 10, 2007
Sequence was last modified on November 14, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 14)
Name and origin of the protein
Protein name GMP reductase
Synonyms EC 1.7.1.7
Guanosine 5'-monophosphate oxidoreductase
Guanosine monophosphate reductase
Gene name
Name: guaC
OrderedLocusNames: LBUL_0246
From
Lactobacillus delbrueckii subsp. bulgaricus (strain ATCC BAA-365) [TaxID: 321956] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae; Lactobacillus.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0607117103; PubMed=17030793 [NCBI, ExPASy, EBI, Israel, Japan]
Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V., Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V., Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M., Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A., Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T., Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
"Comparative genomics of the lactic acid bacteria.";
Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000412; ABJ57912.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_812350.1; -.
3D structure databases
ModBase Q04CB0.
Ontologies
GO
GO:0003920; Molecular function: GMP reductase activity (inferred from electronic annotation from HAMAP).
GO:0006163; Biological process: purine nucleotide metabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01511; -; 1.
PBIL [Tree]
InterPro IPR013785; Aldolase_TIM.
IPR005994; GMP_reduct2.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
Pfam PF00478; IMPDH; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF036500; GMP_red_Firmic; 1.
TIGRFAMs TIGR01306; GMP_reduct_2; 1.
PROSITE PS00487; IMP_DH_GMP_RED; 1.
BLOCKS Q04CB0.
Genome annotation databases
GeneID 4435616; -.
GenomeReviews CP000412_GR; LBUL_0246.
KEGG lbu:LBUL_0246; -.
CMR Q04CB0; LBUL_0246.
Other
ProtoNet Q04CB0.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   330  330     GMP reductase. PRO_0000294274
NP_BIND   209   232  24     NADP (Potential). 
ACT_SITE   180   180        Thioimidate intermediate (By similarity). 
Sequence information
Length: 330 AA [This is the length of the unprocessed precursor] Molecular weight: 36689 Da [This is the MW of the unprocessed precursor] CRC64: C2D44E78A551BA0A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MNNYFSMEAF DYDDIQLVPN KAIVNSRKEC VTSVKFGNRT FKIPVVPANM ESVIDEKLAV 

        70         80         90        100        110        120 
WLAQNGYYYV MHRFQPEKRA DFIKMMHEKG LFASISVGIK DDEYDFIDEL VEKDLIPEYT 

       130        140        150        160        170        180 
TIDVAHGHSV YVIDMIKYIK EKMPDTFLTA GNVATPEAVR ELENAGADAT KVGVGPGKAC 

       190        200        210        220        230        240 
ITKLKTGFGT GGWQLAALRM CSKVARKPLI ADGGIRHNGD IAKSVRFGAS MVMIGSMLAG 

       250        260        270        280        290        300 
HEESPGNVIK IDGKTYKQYW GSASEVQKGA YRNVEGKQML VPYRGSIANT LEEMKEDLQS 

       310        320        330 
SISYAGGRDL ESIKRVDYVI VKNTIMNGDY 

Q04CB0 in FASTA format

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