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UniProtKB/Swiss-Prot entry Q06004


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHSO_BACSU
Primary accession number Q06004
Secondary accession number Q45615
Integrated into Swiss-Prot on February 1, 1994
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 69)
Name and origin of the protein
Protein name Sorbitol dehydrogenase
Synonyms EC 1.1.1.14
L-iditol 2-dehydrogenase
Glucitol dehydrogenase
Gene name
Name: gutB
OrderedLocusNames: BSU06150
From
Bacillus subtilis [TaxID: 1423] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Bacillus.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-32.
STRAIN=168;
PubMed=1460002 [NCBI, ExPASy, EBI, Israel, Japan]
Ng K., Ye R., Wu X.-C., Wong S.-L.;
"Sorbitol dehydrogenase from Bacillus subtilis. Purification, characterization, and gene cloning.";
J. Biol. Chem. 267:24989-24994(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=168;
DOI=10.1038/36786; PubMed=9384377 [NCBI, ExPASy, EBI, Israel, Japan]
Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.;
"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.";
Nature 390:249-256(1997).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.
STRAIN=168;
PubMed=8195086 [NCBI, ExPASy, EBI, Israel, Japan]
Ye R., Wong S.-L.;
"Transcriptional regulation of the Bacillus subtilis glucitol dehydrogenase gene.";
J. Bacteriol. 176:3314-3320(1994).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M96947; AAA22508.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
Z99107; CAB12434.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
L16626; AAA20875.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A45052; A45052.
RefSeq NP_388496.1; -.
3D structure databases
HSSP O96496; 1E3J. [HSSP ENTRY / PDB]
ModBase Q06004.
Enzyme and pathway databases
BioCyc BSUB224308:BSU0615-MON; -.
Organism-specific databases
SubtiList BG10177; gutB. [Micado]
Family and domain databases
InterPro IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002328; AlcDHase_Zn_CS.
Graphical view of domain structure.
PANTHER PTHR11695; ADH_Sf_Zn; 1.
Pfam PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.
PROSITE PS00059; ADH_ZINC; 1.
BLOCKS Q06004.
Genome annotation databases
GeneID 939495; -.
GenomeReviews AL009126_GR; BSU06150.
KEGG bsu:BSU06150; -.
NMPDR fig|224308.1.peg.615; -.
Phylogenomic databases
HOGENOM Q06004; -.
Genome annotation databases
CMR Q06004; BSU06150.
Other
ProtoNet Q06004.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Direct protein sequencing; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   353  352     Sorbitol dehydrogenase. PRO_0000160825
METAL   45    45        Zinc 1; catalytic (By similarity). 
METAL   70    70        Zinc 1; catalytic (By similarity). 
METAL   100   100        Zinc 2 (By similarity). 
METAL   103   103        Zinc 2 (By similarity). 
METAL   106   106        Zinc 2 (By similarity). 
METAL   114   114        Zinc 2 (By similarity). 
METAL   156   156        Zinc 1; catalytic (By similarity). 
Sequence information
Length: 353 AA [This is the length of the unprocessed precursor] Molecular weight: 38390 Da [This is the MW of the unprocessed precursor] CRC64: C87DD26E6DCA74C4 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MTHTVPQNMK AAVMHNTREI KIETLPVPDI NHDEVLIKVM AVGICGSDLH YYTNGRIGNY 

        70         80         90        100        110        120 
VVEKPFILGH ECAGEIAAVG SSVDQFKVGD RVAVEPGVTC GRCEACKEGR YNLCPDVQFL 

       130        140        150        160        170        180 
ATPPVDGAFV QYIKMRQDFV FLIPDSLSYE EAALIEPFSV GIHAAARTKL QPGSTIAIMG 

       190        200        210        220        230        240 
MGPVGLMAVA AAKAFGAGTI IVTDLEPLRL EAAKKMGATH IINIREQDAL EEIKTITNDR 

       250        260        270        280        290        300 
GVDVAWETAG NPAALQSALA SVRRGGKLAI VGLPSQNEIP LNVPFIADNE IDIYGIFRYA 

       310        320        330        340        350 
NTYPKGIEFL ASGIVDTKHL VTDQYSLEQT QDAMERALQF KNECLKVMVY PNR 

Q06004 in FASTA format

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