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UniProtKB/Swiss-Prot entry Q07536

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MMSA_BOVIN
Primary accession number Q07536
Secondary accession numbers None
Integrated into Swiss-Prot on February 1, 1995
Sequence was last modified on February 1, 1995 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 69)
Name and origin of the protein
Protein name Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial [Precursor]
Synonyms MMSDH
Malonate-semialdehyde dehydrogenase [acylating]
EC 1.2.1.27
EC 1.2.1.18
Aldehyde dehydrogenase family 6 member A1
Gene name
Name: ALDH6A1
Synonyms: MMSDH
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Liver;
PubMed=8514806 [NCBI, ExPASy, EBI, Israel, Japan]
Deichaite I., Berthiaume L., Peseckis S.M., Patton W.F., Resh M.D.;
"Novel use of an iodo-myristyl-CoA analog identifies a semialdehyde dehydrogenase in bovine liver.";
J. Biol. Chem. 268:13738-13747(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L08643; AAA30650.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A46600; A46600.
RefSeq NP_787005.1; -.
UniGene Bt.98765
3D structure databases
HSSP Q28399; 1O9J. [HSSP ENTRY / PDB]
ModBase Q07536.
Ontologies
GO
GO:0005739; Cellular component: mitochondrion (inferred from electronic annotation from UniProtKB-KW).
GO:0000062; Molecular function: acyl-CoA binding (inferred from direct assay from UniProtKB).
GO:0018478; Molecular function: malonate-semialdehyde dehydrogenase (acetylating) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0004491; Molecular function: methylmalonate-semialdehyde dehydrogenase (acylating) activity (inferred from direct assay from UniProtKB).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0019859; Biological process: thymine metabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006573; Biological process: valine metabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010061; MeMal-semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
PTHR11699:SF27; MMSDH; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01722; MMSDH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
ProtoNet Q07536.
Genome annotation databases
Ensembl ENSBTAG00000018469; Bos taurus. [Contig view]
GeneID 327692; -.
KEGG bta:327692; -.
Phylogenomic databases
HOVERGEN Q07536; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    34  34     Mitochondrion (By similarity). 
CHAIN   35   537  503     Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial. PRO_0000007188
NP_BIND   211   215  5     NAD (Potential). 
NP_BIND   263   268  6     NAD (Potential). 
ACT_SITE   319   319        Nucleophile (By similarity). 
BINDING   419   419        NAD (Potential). 
MOD_RES   57    57        N6-acetyllysine (By similarity). 
MOD_RES   119   119        N6-acetyllysine (By similarity). 
MOD_RES   333   333        N6-acetyllysine (By similarity). 
CONFLICT   126   127        ML -> TD (in Ref. 1; AA sequence). 
Sequence information
Length: 537 AA [This is the length of the unprocessed precursor] Molecular weight: 58063 Da [This is the MW of the unprocessed precursor] CRC64: 69DF39506E62F9C0 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAAVAVAAAA AALRARILQV SSKVNSSWQP ASSFSSSSVP TVKLFIDGKF IESKSDKWID 

        70         80         90        100        110        120 
IHNPATNEVI GRVPESTKAE MDAAVSSCKR TFPAWADTSI LSRQQVLLRY QQLIKENLKE 

       130        140        150        160        170        180 
IARLIMLEQG KTLADAEGDV FRGLQVVEHA CSVTSLMLGD TMPSITKDMD LYSYRLPLGV 

       190        200        210        220        230        240 
CAGIAPFNFP AMIPLWMFPM AMVCGNTFLM KPSERVPGAT MLLAKLFQDS GAPDGTLNII 

       250        260        270        280        290        300 
HGQHEAVNFI CDHPDIKAIS FVGSNQAGEY IFERGSRHGK RVQANMGAKN HGVVMPDANK 

       310        320        330        340        350        360 
ENTLNQLVGA AFGAAGQRCM ALSTAILVGE AKKWLPELVE RAKKLRVNAG DQPGADLGPL 

       370        380        390        400        410        420 
ITPQAKERVC NLIDSGTKEG ASILLDGRSI KVKGYENGNF VGPTIISNVK PNMTCYKEEI 

       430        440        450        460        470        480 
FGPVLVVLET DTLDEAIKIV NDNPYGNGTA IFTTNGATAR KYSHLVDVGQ VGVNVPIPVP 

       490        500        510        520        530 
LPMFSFTGSR ASFRGDTNFY GKQGIQFYTQ LKTITSQWKE EDASLSSPAV VMPTMGR
Q07536 in FASTA format

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