NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).

Comments

CATALYTIC ACTIVITY: L-tryptophan + O₂ = N-formyl-L-kynurenine.
COFACTOR: Binds 2 heme groups per tetramer. The hemes are protoheme IV (By similarity).
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2 .
INTERACTION:
Self; NbExp=1; IntAct=EBI-316265, EBI-316265;
O62107:gale-1; NbExp=1; IntAct=EBI-316265, EBI-316270;
O61899:kel-8; NbExp=1; IntAct=EBI-316265, EBI-312469;
SIMILARITY: Belongs to the tryptophan 2,3-dioxygenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U20861; AAA62299.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

B88470; B88470.

NP_498284.1; -.

3D structure databases

ModBase

Q09474.

Protein-protein interaction databases

DIP

DIP:26438N; -.

IntAct

Q09474; -.

Organism-specific databases

WormBase

WBGene00016201; C28H8.11.

WormPep

C28H8.11; CE01822. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

Q09474; -.

Ontologies

GO:0042802;	Molecular function: identical protein binding (inferred from physical interaction from IntAct).
GO:0040010;	Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
QuickGo view.

Family and domain databases

InterPro

IPR004981; Trp_2_3_dOase.
Graphical view of domain structure.

PANTHER

PTHR10138; Trp_2_3_dOase; 1.

Pfam

PF03301; Trp_dioxygenase; 1.
Pfam graphical view of domain structure.

BLOCKS

Q09474.

Genome annotation databases

Ensembl

C28H8.11; Caenorhabditis elegans. [Contig view]

GeneID

175836; -.

NMPDR

fig|6239.3.peg.9980; -.

Other

ProtoNet

Q09474.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Dioxygenase; Heme; Iron; Metal-binding; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 403`	`403`		`Putative tryptophan 2,3-dioxygenase.`	`PRO_0000072398`

Sequence information

Length: 403 AA [This is the length of the unprocessed precursor]

Molecular weight: 46716 Da [This is the MW of the unprocessed precursor]

CRC64: 8F1E98075CA86A65 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MACPYLGSGE LTHRVTFMEG GEECQQGVNK VEMGFGQTYS EYLQLDKILT AQRLKSEADG 

        70         80         90        100        110        120 
QRVDDEHLFI VIHQAHELWF KQIIFDLDNV RKLLNNTIVD ETKTLKIVSG LDRMTKILSL 

       130        140        150        160        170        180 
LTEQITLLDT MSPLDFVDFR KYLTPASGFQ SLQFRVLENK LGVRQERRIK YNAQHYKNVF 

       190        200        210        220        230        240 
NDTDLKTLNV TEEEKSLLTL IESWLERTPG LKSTSEDEGF WIKYEKSVNK YLADLAKQAA 

       250        260        270        280        290        300 
DPSNTEEIAK QLTAEYHKTA DAFQSILDPR QHEQHIRNGN RLLSHDATKG AMMIYFYRDM 

       310        320        330        340        350        360 
PRFSQPYQIL TFLMDIDSLF TKWRYNHVLL VQRMLGAKQG TGGSSGYMYL RSTVSDRYKV 

       370        380        390        400 
FLDLFNLSTW LIPREYIPML SPRMVKTLSE HSNLSHSQSS ESD

Q09474 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools