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UniProtKB/Swiss-Prot entry Q09508

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHSA_CAEEL
Primary accession number Q09508
Secondary accession numbers Q17616 Q34089
Integrated into Swiss-Prot on February 1, 1996
Sequence was last modified on August 2, 2002 (Sequence version 3)
Annotations were last modified on    July 22, 2008 (Entry version 73)
Name and origin of the protein
Protein name Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [Precursor]
Synonyms EC 1.3.5.1
Flavoprotein subunit of complex II
FP
Gene name
Name: sdha-1
ORFNames: C03G5.1/D2021.3
From
Caenorhabditis elegans [TaxID: 6239] 
Taxonomy Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Bristol N2;
DOI=10.1016/0166-6851(94)90163-5; PubMed=7739664 [NCBI, ExPASy, EBI, Israel, Japan]
Kuramochi T., Hirawake H., Kojima S., Takamiya S., Furushima R., Aoki T., Komuniecki R., Kita K.;
"Sequence comparison between the flavoprotein subunit of the fumarate reductase (complex II) of the anaerobic parasitic nematode, Ascaris suum and the succinate dehydrogenase of the aerobic, free-living nematode, Caenorhabditis elegans.";
Mol. Biochem. Parasitol. 68:177-187(1994).
[2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D30651; BAA21637.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U41555; AAB37034.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T15398; T15398.
T41753; T41753.
RefSeq NP_509446.1; -.
UniGene Cel.5321
3D structure databases
HSSP P10444; 1NEK. [HSSP ENTRY / PDB]
SMR Q09508; 35-646.
ModBase Q09508.
Organism-specific databases
WormBase WBGene00015391; sdha-1.
WormPep C03G5.1; CE03917. [WormPep / WorfDB]
Gene expression databases
ArrayExpress Q09508; -.
Ontologies
GO
GO:0005743; Cellular component: mitochondrial inner membrane (inferred from sequence or structural similarity from UniProtKB).
GO:0008177; Molecular function: succinate dehydrogenase (ubiquinone) activity (inferred from sequence or structural similarity from UniProtKB).
GO:0010171; Biological process: body morphogenesis (inferred from mutant phenotype from WormBase).
GO:0009792; Biological process: embryonic development ending in birth or egg hatching (inferred from mutant phenotype from WormBase).
GO:0040010; Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR003953; FAD_bind2_N.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR003952; FRD_SDH_FAD_BS.
IPR004112; Fum_Rdtase/Succ_DHase_flav_C.
IPR001100; Pyr_nuc-diS_OxRdtase.
IPR011281; Succ_DHase_flav_su_fwd.
IPR014006; Succ_Dhase_frdA_Gneg.
Graphical view of domain structure.
Pfam PF00890; FAD_binding_2; 1.
PF02910; Succ_DH_flav_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00368; FADPNR.
PR00411; PNDRDTASEI.
TIGRFAMs TIGR01816; sdhA_forward; 1.
TIGR01812; sdhA_frdA_Gneg; 1.
PROSITE PS00504; FRD_SDH_FAD_BINDING; 1.
BLOCKS Q09508.
Genome annotation databases
Ensembl C03G5.1; Caenorhabditis elegans. [Contig view]
GeneID 181108; -.
KEGG cel:C03G5.1; -.
Other
ProtoNet Q09508.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Electron transport; FAD; Flavoprotein; Membrane; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transport; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    31  31     Mitochondrion (Potential). 
CHAIN   32   646  615     Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial. PRO_0000010339
NP_BIND   72    87  16     FAD (By similarity). 
ACT_SITE   321   321        Proton acceptor (By similarity). 
BINDING   277   277        Substrate (By similarity). 
BINDING   289   289        Substrate (By similarity). 
BINDING   388   388        Substrate (By similarity). 
BINDING   433   433        Substrate (By similarity). 
MOD_RES   80    80        Tele-8alpha-FAD histidine (By similarity). 
CONFLICT   64    64        G -> E (in Ref. 1; BAA21637). 
CONFLICT   267   267        N -> S (in Ref. 1; BAA21637). 
CONFLICT   303   303        A -> S (in Ref. 1; BAA21637). 
CONFLICT   315   315        A -> S (in Ref. 1; BAA21637). 
CONFLICT   463   463        V -> G (in Ref. 1; BAA21637). 
CONFLICT   483   486        HNKG -> TTRE (in Ref. 1; BAA21637). 
CONFLICT   640   640        P -> A (in Ref. 1; BAA21637). 
Sequence information
Length: 646 AA [This is the length of the unprocessed precursor] Molecular weight: 70398 Da [This is the MW of the unprocessed precursor] CRC64: CD7CF55A6D26E6D1 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLRAASNGLR NTVAARSVSL SAANHSDAKR SDIAQYKVVD HAYDAVVVGA GGAGLRAAMG 

        70         80         90        100        110        120 
LAEGGLKTAV ITKLFPTRSH TVAAQGGINA ALGNMNPDNW RWHFYDTVKG SDWLGDQDAI 

       130        140        150        160        170        180 
HYMTREAERA VIELENYGMP FSRTTDGKIY QRAFGGQSND FGRGGQAHRT CCVADRTGHS 

       190        200        210        220        230        240 
LLHTLYGASL QYNCNYFVEY FALDLIMENG VCVGVIAMDL EDGTIHRFRS KNTVLATGGY 

       250        260        270        280        290        300 
GRAFFSCTSA HTCTGDGTAL TARAGINNSD MEFVQFHPTG IYGAGCLITE GSRGEGGYLV 

       310        320        330        340        350        360 
NSAGERFMER YAPNAKDLAS RDVVSRSMTV EIMEGRGVGP DKDHIYLQLH HLPAEQLQQR 

       370        380        390        400        410        420 
LPGISETAMI FAGVDVTKEP IPVIPTVHYN MGGVPTNYKG QVLNYTPKKG DEVVPGLYAA 

       430        440        450        460        470        480 
GECGAHSVHG ANRLGANSLL DLVIFGRACA IDILKNTSAG VGVPELPKNA GEASVANIDK 

       490        500        510        520        530        540 
LRHNKGDIST AELRLTMQKS MQNHAAVFRR GDILKEGVKV LSKLYKDQAH LNVADKGLVW 

       550        560        570        580        590        600 
NSDLIETLEL QNLLINATQT IVAAENREES RGAHARDDFP DRLDELDYSK PLEGQTKKEL 

       610        620        630        640 
KDHWRKHSII RSNIETGEVS LDYRPVIDTT LDKSETDWVP PKVRSY
Q09508 in FASTA format

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