NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
DOI=10.1126/science.282.5396.2012; PubMed=9851916 [NCBI, ExPASy, EBI, Israel, Japan]
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating biology.";
Science 282:2012-2018(1998).

Comments

FUNCTION: Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).
CATALYTIC ACTIVITY: Succinate + ubiquinone = fumarate + ubiquinol.
COFACTOR: Binds 1 2Fe-2S cluster (By similarity).
COFACTOR: Binds 1 3Fe-4S cluster (By similarity).
COFACTOR: Binds 1 4Fe-4S cluster (By similarity).
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle .
SUBUNIT: Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
SIMILARITY: Contains 1 2Fe-2S ferredoxin-type domain.
SIMILARITY: Contains 1 4Fe-4S ferredoxin-type domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z47809; CAA87780.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

T22083; T22083.

NP_495992.1; -.

3D structure databases

HSSP

P07014; 1NEK. [HSSP ENTRY / PDB]

SMR

Q09545; 51-287.

ModBase

Q09545.

Organism-specific databases

WormBase

WBGene00006433; tag-55.

WormPep

F42A8.2; CE01579. [WormPep / WorfDB]

Gene expression databases

ArrayExpress

Q09545; -.

Ontologies

GO:0010171;	Biological process: body morphogenesis (inferred from mutant phenotype from WormBase).
GO:0009792;	Biological process: embryonic development ending in birth or egg hatching (inferred from mutant phenotype from WormBase).
GO:0002119;	Biological process: nematode larval development (inferred from mutant phenotype from WormBase).
GO:0040010;	Biological process: positive regulation of growth rate (inferred from mutant phenotype from WormBase).
QuickGo view.

Family and domain databases

InterPro

IPR006058; 2Fe2S_fd_BS.
IPR001450; 4Fe4S_Fe_S_bd.
IPR012675; b-grasp_ferredoxin-like.
IPR001041; Ferredoxin.
IPR012285; Fum_reductase_C.
IPR004489; Succ_DHase/fum_Rdtase_Fe-S.
Graphical view of domain structure.

Gene3D

G3DSA:3.10.20.30; Ferredoxin_fold; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.

Pfam

PF00111; Fer2; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00384; dhsB; 1.

PROSITE

PS00197; 2FE2S_FER_1; 1.
PS51085; 2FE2S_FER_2; 1.
PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q09545.

Genome annotation databases

Ensembl

F42A8.2; Caenorhabditis elegans. [Contig view]

GeneID

174482; -.

KEGG

cel:F42A8.2; -.

Other

ProtoNet

Q09545.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

2Fe-2S; 3Fe-4S; 4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Transit peptide; Transport; Tricarboxylic acid cycle.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion (Potential).`
`CHAIN`	`? 298`		`Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial.`	`PRO_0000010354`
`DOMAIN`	`59 147`	`89`	`2Fe-2S ferredoxin-type.`
`DOMAIN`	`190 220`	`31`	`4Fe-4S ferredoxin-type.`
`METAL`	`107 107`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`112 112`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`115 115`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`127 127`		`Iron-sulfur 1 (2Fe-2S) (By similarity).`
`METAL`	`200 200`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`203 203`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`206 206`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`METAL`	`210 210`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`257 257`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`263 263`		`Iron-sulfur 3 (3Fe-4S) (By similarity).`
`METAL`	`267 267`		`Iron-sulfur 2 (4Fe-4S) (By similarity).`
`BINDING`	`215 215`		`Ubiquinone; shared with DHSD (By similarity).`

Sequence information

Length: 298 AA [This is the length of the unprocessed precursor]

Molecular weight: 32891 Da [This is the MW of the unprocessed precursor]

CRC64: 0FDD148A6C9AB824 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLARSARLLH SAELAANAIR AASGAPATAA AAEASFPSTD DVAAKTKKTG NRIKTFEIYR 

        70         80         90        100        110        120 
FNPEAPGAKP TVQKFDVDLD QCGTMILDAL IKIKNEVDPT LTFRRSCREG ICGSCAMNIG 

       130        140        150        160        170        180 
GQNTLACICK IDSDTSKSTK IYPLPHMFVV KDLVPDMNLF YAQYASIQPW IQKKTPLTLG 

       190        200        210        220        230        240 
EKQMHQSVAE RDRLDGLYEC ILCACCSTSC PSYWWNADKY LGPAVLMQAY RWVIDSRDDY 

       250        260        270        280        290 
ATERLHRMHD SFSAFKCHTI MNCTKTCPKH LNPAKAIGEI KSLLTGFTSK PAAEPSAF

Q09545 in FASTA format

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View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools