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UniProtKB/Swiss-Prot entry Q09736


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name CP51_SCHPO
Primary accession number Q09736
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1995
Sequence was last modified on November 1, 1995 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 62)
Name and origin of the protein
Protein name Cytochrome P450 51 [Precursor]
Synonyms EC 1.14.13.70
CYPLI
P450-LIA1
Sterol 14-alpha demethylase erg11
Lanosterol 14-alpha demethylase erg11
P450-14DM
Gene name
Name: erg11
Synonyms: cyp51
ORFNames: SPAC13A11.02c
From
Schizosaccharomyces pombe (Fission yeast) [TaxID: 4896] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 38366 / 972;
DOI=10.1038/nature724; PubMed=11859360 [NCBI, ExPASy, EBI, Israel, Japan]
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[2]
INDUCTION.
DOI=10.1128/MCB.26.7.2817-2831.2006; PubMed=16537923 [NCBI, ExPASy, EBI, Israel, Japan]
Todd B.L., Stewart E.V., Burg J.S., Hughes A.L., Espenshade P.J.;
"Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.";
Mol. Cell. Biol. 26:2817-2831(2006).
[3]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
DOI=10.1038/nbt1222; PubMed=16823372 [NCBI, ExPASy, EBI, Israel, Japan]
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S., Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S., Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
[4]
IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH DAP1.
DOI=10.1016/j.cmet.2006.12.009; PubMed=17276356 [NCBI, ExPASy, EBI, Israel, Japan]
Hughes A.L., Powell D.W., Bard M., Eckstein J., Barbuch R., Link A.J., Espenshade P.J.;
"Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes.";
Cell Metab. 5:143-149(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CU329670; CAA90803.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T37609; T37609.
RefSeq NP_592990.1; -.
3D structure databases
HSSP P77901; 1E9X. [HSSP ENTRY / PDB]
ModBase Q09736.
Enzyme and pathway databases
BioCyc SPOM-XXX-01:SPOM-XXX-01-000714-MON; -.
Organism-specific databases
GeneDB_Spombe SPAC13A11.02c; -.
Gene expression databases
ArrayExpress Q09736; -.
Ontologies
GO
GO:0005783; Cellular component: endoplasmic reticulum (inferred from direct assay from GeneDB_SPombe).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from GeneDB_SPombe).
GO:0006696; Biological process: ergosterol biosynthetic process (inferred from expression pattern from GeneDB_SPombe).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002403; Cyt_P450_E_grp-IV.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00465; EP450IV.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS Q09736.
Genome annotation databases
GeneID 2542599; -.
KEGG spo:SPAC13A11.02c; -.
NMPDR fig|4896.1.peg.2960; -.
Other
ProtoNet Q09736.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Endoplasmic reticulum; Heme; Iron; Lipid synthesis; Membrane; Metal-binding; Monooxygenase; NADP; Oxidoreductase; Signal; Steroid biosynthesis; Sterol biosynthesis; Stress response; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    15  15     Potential. 
CHAIN   16   495  480     Cytochrome P450 51. PRO_0000052009
TRANSMEM   35    55  21     Potential. 
TRANSMEM   283   303  21     Potential. 
METAL   442   442        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 495 AA [This is the length of the unprocessed precursor] Molecular weight: 56331 Da [This is the MW of the unprocessed precursor] CRC64: 193333395F6C8B31 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAFSLVSILL SIALAWYVGY IINQLTSRNS KRPPIVFHWI PFVGSAVAYG MDPYVFFREC 

        70         80         90        100        110        120 
RAKYGDVFTF VCMGRKMTAF LGVQGNDFLF NGKLADLNAE EAYSHLTTPV FGKDVVYDIP 

       130        140        150        160        170        180 
NHVFMEHKKF IKSGLGFSQF RSYVPLILNE MDAFLSTSPD FGPGKEGVAD LLKTMPVMTI 

       190        200        210        220        230        240 
YTASRTLQGA EVRKGFDAGF ADLYHDLDQG FSPVNFVFPW LPLPRNRRRD RAHKIMQKTY 

       250        260        270        280        290        300 
LKIIKDRRSS TENPGTDMIW TLMSCKYRDG RPLKEHEIAG MMIALLMAGQ HTSAATIVWV 

       310        320        330        340        350        360 
LALLGSKPEI IEMLWEEQKR VVGENLELKF DQYKDMPLLN YVIQETLRLH PPIHSHMRKV 

       370        380        390        400        410        420 
KRDLPVPGSK IVIPANNYLL AAPGLTATEE EYFTHATDFD PKRWNDRVNE DENAEQIDYG 

       430        440        450        460        470        480 
YGLVTKGAAS PYLPFGAGRH RCIGEQFAYM HLSTIISKFV HDYTWTLIGK VPNVDYSSMV 

       490 
ALPLGPVKIA WKRRN 

Q09736 in FASTA format

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