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UniProtKB/Swiss-Prot entry Q0AWX5


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FOLD2_SYNWW
Primary accession number Q0AWX5
Secondary accession numbers None
Integrated into Swiss-Prot on December 12, 2006
Sequence was last modified on October 17, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 14)
Name and origin of the protein
Protein name Bifunctional protein folD 2
Synonyms None
Includes Methylenetetrahydrofolate dehydrogenase
     (EC 1.5.1.5)
Methenyltetrahydrofolate cyclohydrolase
     (EC 3.5.4.9)
Gene name
Name: folD2
OrderedLocusNames: Swol_1474
From
Syntrophomonas wolfei subsp. wolfei (strain Goettingen) [TaxID: 335541] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Clostridia; Clostridiales; Syntrophomonadaceae; Syntrophomonas.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S., Brettin T., Sims D., Bruce D., Han C., Tapia R., Gilna P., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Boone D.R., Brockman F., Culley D., Ferry J., Gunsalus R., McInerney M.J., Morrison M., Plugge C., Rohlin L., Scholten J., Sieber J., Stams A.J.M., Richardson P.;
"Complete sequence of Syntrophomonas wolfei subsp. wolfei str. Goettingen.";
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000448; ABI68779.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_754150.1; -.
3D structure databases
ModBase Q0AWX5.
Ontologies
GO
GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01576; -; 1.
PBIL [Tree]
InterPro IPR016040; NAD(P)-bd.
IPR000672; THF_DHase/CycOHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00763; THF_DHG_CYH; 1.
PF02882; THF_DHG_CYH_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00085; THFDHDRGNASE.
ProDom PD002300; THFDhg/Cyc_hydro; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00766; THF_DHG_CYH_1; FALSE_NEG.
PS00767; THF_DHG_CYH_2; FALSE_NEG.
BLOCKS Q0AWX5.
Genome annotation databases
GeneID 4282339; -.
GenomeReviews CP000448_GR; Swol_1474.
KEGG swo:Swol_1474; -.
Phylogenomic databases
HOGENOM Q0AWX5; -.
Genome annotation databases
CMR Q0AWX5; Swol_1474.
Other
ProtoNet Q0AWX5.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP; One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   272  272     Bifunctional protein folD 2. PRO_0000268540
Sequence information
Length: 272 AA [This is the length of the unprocessed precursor] Molecular weight: 29705 Da [This is the MW of the unprocessed precursor] CRC64: 934297BA64716B37 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MLIYGKDIRE QIKERVRQSA EEVKMGLAII RVGDDPSSMA YVRGIRKFAE ETGVKVEIVN 

        70         80         90        100        110        120 
LPDAVGEREL LKTIGDLNNS SEITGIMLQT PLPASLNASH LVNAIDFDKD VEGIHNYNLG 

       130        140        150        160        170        180 
KLISKEEGVR PCTPKAVISM LKAHDILIEG QKVTIIGRSM TVGSPLALMM TAENATVTVC 

       190        200        210        220        230        240 
HTRTRNLKEE ALRADILVAA VGKREFVTAD MVHKDMVVID VGINFDENGK MLGDVHEEAR 

       250        260        270 
NHCRLASAVP GGIGVITVAE LFDNLRILSQ KA 

Q0AWX5 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

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