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UniProtKB/Swiss-Prot entry Q0DY59

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HMDH1_ORYSJ
Primary accession number Q0DY59
Secondary accession number P48019
Integrated into Swiss-Prot on July 24, 2007
Sequence was last modified on July 24, 2007 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 19)
Name and origin of the protein
Protein name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1
Synonyms HMG-CoA reductase 1
EC 1.1.1.34
Gene name
Name: HMG1
OrderedLocusNames: Os02g0713900, LOC_Os02g48330
From
Oryza sativa subsp. japonica (Rice) [TaxID: 39947] 
Taxonomy Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Poales; Poaceae; BEP clade; Ehrhartoideae; Oryzeae; Oryza.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Nipponbare;
DOI=10.1038/nature03895; PubMed=16100779 [NCBI, ExPASy, EBI, Israel, Japan]
International rice genome sequencing project (IRGSP);
"The map-based sequence of the rice genome.";
Nature 436:793-800(2005).
[2]
 GENOME REANNOTATION.
STRAIN=cv. Nipponbare;
DOI=10.1101/gr.5509507; PubMed=17210932 [NCBI, ExPASy, EBI, Israel, Japan]
The rice annotation project (RAP);
"Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana.";
Genome Res. 17:175-183(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AP008208; BAF09829.1; ALT_SEQ; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001047915.1; -.
UniGene Os.164
3D structure databases
HSSP P04035; 1DQA. [HSSP ENTRY / PDB]
ModBase Q0DY59.
Organism-specific databases
Gramene P48019; -.
Ontologies
GO
GO:0005789; Cellular component: endoplasmic reticulum membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR002202; HMG_CoA_Rdtase_cat.
IPR004554; HMG_CoA_Rdtase_I_cat.
Graphical view of domain structure.
PRINTS PR00071; HMGCOARDTASE.
TIGRFAMs TIGR00533; HMG_CoA_R_NADP; 1.
PROSITE PS00066; HMG_COA_REDUCTASE_1; 1.
PS00318; HMG_COA_REDUCTASE_2; 1.
PS01192; HMG_COA_REDUCTASE_3; 1.
PS50065; HMG_COA_REDUCTASE_4; 1.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q0DY59.
Genome annotation databases
GeneID 4330509; -.
KEGG osa:4330509; -.
Other
ProtoNet Q0DY59.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Endoplasmic reticulum; Glycoprotein; Isoprene biosynthesis; Membrane; NADP; Oxidoreductase; Transmembrane.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   532  532     3-hydroxy-3-methylglutaryl-coenzyme A reductase 1. PRO_0000114446
TRANSMEM   63    83  21     Potential. 
REGION   77   117  41     Linker (By similarity). 
REGION   118   532  415     Catalytic (By similarity). 
ACT_SITE   211   211        Charge relay system (By similarity). 
ACT_SITE   343   343        Charge relay system (By similarity). 
ACT_SITE   419   419        Charge relay system (By similarity). 
ACT_SITE   517   517        Proton donor (By similarity). 
CARBOHYD   275   275        N-linked (GlcNAc...) (Potential). 
CARBOHYD   521   521        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 532 AA [This is the length of the unprocessed precursor] Molecular weight: 55615 Da [This is the MW of the unprocessed precursor] CRC64: D70406C15BA50127 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MDVRRGGGGG RIVGAARRAL TWGALPLPMR ITNGLAMVSL VLSSCDLLRL CSDRERPLGG 

        70         80         90        100        110        120 
REFATVVYLV SLFAHPDAPA TTTGDDDDGQ GGSRRARPAA AEPAPMHGHG GGMMEADDEE 

       130        140        150        160        170        180 
IVAAVASGAL PSHRLESRLG DCRRAARLRR EALRRVTGRG VEGLPFDGMD YQAILGQCCE 

       190        200        210        220        230        240 
MPVGYVQLPV GVAGPLLLDG REYHVPMATT EGCLVASVNR GCRAISASGG AFSVLLRDAM 

       250        260        270        280        290        300 
SRAPAVKLPS AMRAAELKAF AEAPANFELL AAVFNRSSRF GRLQDIRCAL AGRNLYMRFS 

       310        320        330        340        350        360 
CITGDAMGMN MVSKGVENVL GYLQNVFPDM DVISVSGNYC SDKKPTAVNW IEGRGKSVVC 

       370        380        390        400        410        420 
EAIIKGDVVQ KVLKTTVEKL VELNIIKNLA GSAVAGALGG FNAHASNIVT ALFIATGQDP 

       430        440        450        460        470        480 
AQNVESSQCI TMLEEVNDGD DLHISVTMPS IEVGTIGGGT CLASQAACLN LLGVKGSNHG 

       490        500        510        520        530 
SPGANAKRLA TIVAGSVLAG ELSLLAALAS GHLVKSHMMY NRSSKDVAKA AS
Q0DY59 in FASTA format

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