NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/j.gene.2006.03.015; PubMed=16828987 [NCBI, ExPASy, EBI, Israel, Japan]
Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.;
"Adaptive selection of mitochondrial complex I subunits during primate radiation.";
Gene 378:11-18(2006).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
COFACTOR: Binds 1 4Fe-4S cluster.
SUBUNIT: Complex I is composed of 45 different subunits. Component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Peripheral membrane protein; Matrix side (By similarity).
SIMILARITY: Belongs to the complex I 49 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ885670; ABH12179.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q0MQG4.

Ontologies

GO:0005747;	Cellular component: mitochondrial respiratory chain complex I (inferred from sequence or structural similarity from UniProtKB).
GO:0006979;	Biological process: response to oxidative stress (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR014029; NADH-UbQ_OxRdtase_49kDa_CS.
IPR010219; NADH_DH_1_dsu.
IPR001135; NADH_UbQ_OxRdtase_49kDa.
Graphical view of domain structure.

Pfam

PF00346; Complex1_49kDa; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01962; NuoD; 1.

PROSITE

PS00535; COMPLEX1_49K; 1.

BLOCKS

Q0MQG4.

Phylogenomic databases

HOVERGEN

Q0MQG4; -.

Other

ProtoNet

Q0MQG4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Electron transport; Iron; Iron-sulfur; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; Transit peptide; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 33`	`33`	`Mitochondrion (By similarity).`
`CHAIN`	`34 463`	`430`	`NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial.`	`PRO_0000251856`
`METAL`	`326 326`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`332 332`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`347 347`		`Iron-sulfur (4Fe-4S) (Potential).`

Sequence information

Length: 463 AA [This is the length of the unprocessed precursor]

Molecular weight: 52558 Da [This is the MW of the unprocessed precursor]

CRC64: 25D39B077D5C63A3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAALRVLCGL RGVAAQVLRP GAGVRLPIQP SRGVRQWQPD VEWAQQFGGA VMYPSKETAH 

        70         80         90        100        110        120 
WKPPPWNDVD PPKDTIVKNM TLNFGPQHPA AHGVLRLVME LSGEMVRKCD PHIGLLHRGT 

       130        140        150        160        170        180 
EKLIEYKTYL QALPYFDRLD YVSMMCNEQA YSLAVEKLLN IRPPPRAQWI RVLFGEITRL 

       190        200        210        220        230        240 
LNHIMAVTTH ALDLGAMTPF FWLFEEREKM FEFYERVSGA RMHAAYIRPG GVHQDLPLGL 

       250        260        270        280        290        300 
MDDIYQFSKN FSLRLDELEE LLTNNRIWRN RTIDIGVVTA EEALNYGFSG VMLRGSGIQW 

       310        320        330        340        350        360 
DLRKTQPYDV YDQVEFDVPV GSRGDCYDRY LCRVEEMRQS LRIIAQCLNK MPPGEIKVDD 

       370        380        390        400        410        420 
AKVSPPKRAE MKTSMESLIH HFKLYTEGYQ VPPGATYTAI EAPKGEFGVY LVSDGSSRPY 

       430        440        450        460 
RCKIKAPGFA HLAGLDKMSK GHMLADVVAI IGTQDIVFGE VDR

Q0MQG4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools