NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/j.gene.2006.03.015; PubMed=16828987 [NCBI, ExPASy, EBI, Israel, Japan]
Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.;
"Adaptive selection of mitochondrial complex I subunits during primate radiation.";
Gene 378:11-18(2006).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
SUBUNIT: Complex I is composed of 45 different subunits (By similarity).
SUBCELLULAR LOCATION: Mitochondrion inner membrane (By similarity). Note=Matrix and cytoplasmic side of the mitochondrial inner membrane (By similarity).
SIMILARITY: Belongs to the complex I 30 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ885667; ABH12176.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

ModBase

Q0MQG7.

Ontologies

GO:0005747;	Cellular component: mitochondrial respiratory chain complex I (inferred from sequence or structural similarity from UniProtKB).
GO:0003954;	Molecular function: NADH dehydrogenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0006917;	Biological process: induction of apoptosis (inferred from sequence or structural similarity from UniProtKB).
GO:0030308;	Biological process: negative regulation of cell growth (inferred from sequence or structural similarity from UniProtKB).
GO:0006800;	Biological process: oxygen and reactive oxygen species metabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR010218; NADH_DH_csu.
IPR001268; NADH_DHase_Ub_30kDa_su.
Graphical view of domain structure.

Pfam

PF00329; Complex1_30kDa; 1.
Pfam graphical view of domain structure.

ProDom

PD001581; Complex1_30K; 1.
[Domain structure / List of seq. sharing at least 1 domain]

TIGRFAMs

TIGR01961; NuoC_fam; 1.

PROSITE

PS00542; COMPLEX1_30K; 1.

BLOCKS

Q0MQG7.

Phylogenomic databases

HOVERGEN

Q0MQG7; -.

Other

ProtoNet

Q0MQG7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane; NAD; Oxidoreductase; Respiratory chain; Transit peptide; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 35`	`35`	`Mitochondrion (By similarity).`
`CHAIN`	`36 263`	`228`	`NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial.`	`PRO_0000251859`

Sequence information

Length: 263 AA [This is the length of the unprocessed precursor]

Molecular weight: 30168 Da [This is the MW of the unprocessed precursor]

CRC64: C7154727148956B5 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MVAAVARLWW RGLLGASALT RGAGRPSVLL LPVRRESAGA DTRPTVRPRN DVAHKQLSAF 

        70         80         90        100        110        120 
GEYVAEILPK YVQQVQVSCF NELEVCIHPD GVIPVLTFLR DHTNAQFKSL VDLTAVDVPT 

       130        140        150        160        170        180 
RQNRFEIVYN LLSLRFNSRI RVKTYTDELT PIESAVSVFK AANWYEREIW DMFGVFFANH 

       190        200        210        220        230        240 
PDLRRILTDY GFEGHPFRKD FPLSGYVELR YDDEVKRVVA EPVELAQEFR KFDLNSPWEA 

       250        260 
FPVYRQPPES LKLEAGDKKP DAK

Q0MQG7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools