NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1016/j.gene.2006.03.015; PubMed=16828987 [NCBI, ExPASy, EBI, Israel, Japan]
Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V., Gaut B., Wallace D.C.;
"Adaptive selection of mitochondrial complex I subunits during primate radiation.";
Gene 378:11-18(2006).

Comments

FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
CATALYTIC ACTIVITY: NADH + ubiquinone = NAD⁺ + ubiquinol.
CATALYTIC ACTIVITY: NADH + acceptor = NAD⁺ + reduced acceptor.
COFACTOR: Binds 1 4Fe-4S cluster (Potential).
SUBUNIT: Complex I is composed of 45 different subunits This is a component of the iron-sulfur (IP) fragment of the enzyme (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
SIMILARITY: Belongs to the complex I 20 kDa subunit family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ885654; ABH12163.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001103713.1; -.

3D structure databases

ModBase

Q0MQI0.

Ontologies

GO:0005747;	Cellular component: mitochondrial respiratory chain complex I (inferred from sequence or structural similarity from UniProtKB).
GO:0005515;	Molecular function: protein binding (inferred from sequence or structural similarity from UniProtKB).
GO:0032981;	Biological process: mitochondrial respiratory chain complex I assembly (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR006138; NADH_DHase_20kDa_su.
IPR014406; NiFe_hyd_3_ssu/Q_oxred_NuoB.
IPR006137; OxRdtase_q6.
Graphical view of domain structure.

PANTHER

PTHR11995:SF2; NADH_DH_20kDa; 1.
PTHR11995; NiFe_hyd_3_ssu/Q_oxred_NuoB; 1.

Pfam

PF01058; Oxidored_q6; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR01957; nuoB_fam; 1.

PROSITE

PS01150; COMPLEX1_20K; 1.

BLOCKS

Q0MQI0.

Genome annotation databases

GeneID

100126358; -.

KEGG

ptr:100126358; -.

Phylogenomic databases

HOVERGEN

Q0MQI0; -.

Other

ProtoNet

Q0MQI0.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding; Mitochondrion; NAD; Oxidoreductase; Respiratory chain; Transit peptide; Transport; Ubiquinone.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 38`	`38`	`Mitochondrion (By similarity).`
`CHAIN`	`39 213`	`175`	`NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial.`	`PRO_0000251873`
`METAL`	`88 88`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`89 89`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`153 153`		`Iron-sulfur (4Fe-4S) (Potential).`
`METAL`	`183 183`		`Iron-sulfur (4Fe-4S) (Potential).`

Sequence information

Length: 213 AA [This is the length of the unprocessed precursor]

Molecular weight: 23594 Da [This is the MW of the unprocessed precursor]

CRC64: BA80777F8F97C1A4 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAVLSAPGLR GFRILGLRSS VGPAVQARSV HQSVATDGPS STQPALPKAR AVAPKPSSRG 

        70         80         90        100        110        120 
EYVVAKLDDL VNWARRSSLW PMTFGLACCA VEMMHMAAPR YDMDRFGVVF RASPRQSDVM 

       130        140        150        160        170        180 
IVAGTLTNKM APALRKVYDQ MPEPRYVVSM GSCANGGGYY HYSYSVVRGC DRIVPVDIYI 

       190        200        210 
PGCPPTAEAL LYGILQLQRK IKRERRLQIW YRR

Q0MQI0 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools