[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Kidney; Ibrahim H.M., Curthoys N.P.; "Sus scrofa renal zeta-crystallin (NADPH quinone reductase) cDNA."; Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones are the best substrates. May act in the detoxification of xenobiotics (By similarity).
CATALYTIC ACTIVITY: NADPH + quinone = NADP⁺ + semiquinone.
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Cytoplasm (By similarity).
SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.

Copyright

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Cross-references

Sequence databases

EMBL

DQ841573; ABH10011.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q0MVN8; 6-329.

ModBase

Q0MVN8.

Family and domain databases

InterPro

IPR013154; AlcDHase_GroES-like.
IPR002085; AlcDHase_SF_Zn.
IPR013149; AlcDHase_Zn-bd.
IPR002364; Quin_OxRdtase/zeta-crystal_CS.
Graphical view of domain structure.

PANTHER

PTHR11695; ADH_Sf_Zn; 1.

Pfam

PF08240; ADH_N; 1.
PF00107; ADH_zinc_N; 1.
Pfam graphical view of domain structure.

PROSITE

PS01162; QOR_ZETA_CRYSTAL; 1.

BLOCKS

Q0MVN8.

Phylogenomic databases

HOVERGEN

Q0MVN8; -.

Other

ProtoNet

Q0MVN8.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 329`	`329`		`Quinone oxidoreductase.`	`PRO_0000251735`

Sequence information

Length: 329 AA [This is the length of the unprocessed precursor]

Molecular weight: 34997 Da [This is the MW of the unprocessed precursor]

CRC64: 2D62ECE3555D0AC3 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MATGQKLMSA IRVFKFGGPE VMKLQSDVAI PIPKDNQVLI KVHACGVNPV DTYIRSGTHN 

        70         80         90        100        110        120 
MKPLLPYTPG LDVAGIVEAV GEHVSSFKKG DRVFTVSTLS GGYAEYALAA DDTVYMLPEK 

       130        140        150        160        170        180 
LDFKQGAAIG IPYFTACLAL LHSACVKAGE IVLIHGASGG VGIAACQIAR AYGLKVLGTA 

       190        200        210        220        230        240 
GTEEGQNIVL QNGAHEVFNH REVNYIDKIK KSVGEKGIDV IIEMLANVNL SNDLNLLSHG 

       250        260        270        280        290        300 
GRVIIVGSRG PIEINPRDTM TKGSSIKGVA LYSSTKEEFQ QLAAALQAGM EVGWLRPVIG 

       310        320 
PVYPLEKAAQ AHEDIIHSRG ATGKMILLL

Q0MVN8 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools