[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Ascending colon; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML) (By similarity).
CATALYTIC ACTIVITY: N₆,N₆,N⁶-trimethyl-L-lysine + 2-oxoglutarate + O₂ = 3-hydroxy-N₆,N₆,N⁶-trimethyl-L-lysine + succinate + CO₂.
COFACTOR: Iron (By similarity).
COFACTOR: Ascorbate (By similarity).
PATHWAY: Amine and polyamine biosynthesis; carnitine biosynthesis .
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Mitochondrion matrix (By similarity).
SIMILARITY: Belongs to the gamma-BBH/TMLD family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC120318; AAI20319.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001069532.1; -.

UniGene

Bt.21098

3D structure databases

ModBase

Q0VC74.

Ontologies

GO:0005759;	Cellular component: mitochondrial matrix (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.

Family and domain databases

InterPro

IPR003819; Taurine_dOase.
IPR012776; Trimethyllysine_dOase.
Graphical view of domain structure.

PANTHER

PTHR10696:SF2; tMLys_dOase; 1.

Pfam

PF02668; TauD; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR02410; carnitine_TMLD; 1.

BLOCKS

Q0VC74.

Genome annotation databases

Ensembl

ENSBTAG00000011648; Bos taurus. [Contig view]

GeneID

535630; -.

KEGG

bta:535630; -.

Phylogenomic databases

HOVERGEN

Q0VC74; -.

Other

ProtoNet

Q0VC74.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Carnitine biosynthesis; Dioxygenase; Iron; Mitochondrion; Oxidoreductase; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 ?`		`Mitochondrion (Potential).`
`CHAIN`	`? 421`		`Trimethyllysine dioxygenase, mitochondrial.`	`PRO_0000260156`

Sequence information

Length: 421 AA [This is the length of the unprocessed precursor]

Molecular weight: 49837 Da [This is the MW of the unprocessed precursor]

CRC64: 6FADE146279CA760 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MWCHRLSHLQ SRLQDLLRGR VTRWALQQSN FKSLFPLAIY WHHTASKSLN CVWQQHEDHF 

        70         80         90        100        110        120 
ELQYANNVMR FDYVWLRDHC RSASCYNSKT HQRSLDTASV DLCIQPQTIH LDETTLFFTW 

       130        140        150        160        170        180 
PDGHVTRYDL DWLMKNSYEG QKQKVIQPRI LWNAEIYQQA QVPAVDFQTF LETKEGLKNF 

       190        200        210        220        230        240 
LQNFLLYGIA FVENVPPTQK HTEKLAERIS LIRETIYGRM WFFTSDFSRG DTAYTKLALD 

       250        260        270        280        290        300 
RHTDTTYFQE PCGIQVFHCL KHEGTGGRTL LVDGFYAAEQ VLQKAPEEFE LLSKVPLKHE 

       310        320        330        340        350        360 
YIENVGECQN HMIGVGPVLN IYPWNKELYL IRYNNYDRAV INTVPYDVVH RWYTAHRTLT 

       370        380        390        400        410        420 
RELRRPENEF WVKLKPGKVL FIDNWRVLHG RESFTGYRQL CGCYLTRDDV LNTARLLGLQ 


A

Q0VC74 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools