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UniProtKB/Swiss-Prot entry Q12659

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name ARO1_PNECA
Primary accession number Q12659
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 62)
Name and origin of the protein
Protein name Pentafunctional AROM polypeptide
Synonyms None
Includes 3-dehydroquinate synthase
     (EC 4.2.3.4)
3-phosphoshikimate 1-carboxyvinyltransferase
     (EC 2.5.1.19)
     (5-enolpyruvylshikimate-3-phosphate synthase)
     (EPSP synthase)
     (EPSPS)
Shikimate kinase
     (EC 2.7.1.71)
3-dehydroquinate dehydratase
     (3-dehydroquinase)
     (EC 4.2.1.10)
Shikimate dehydrogenase
     (EC 1.1.1.25)
Gene name
Name: AROM
From
Pneumocystis carinii [TaxID: 4754] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Pneumocystidomycetes; Pneumocystidaceae; Pneumocystis.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8126418 [NCBI, ExPASy, EBI, Israel, Japan]
Banerji S., Wakefield A.E., Allen A.G., Maskell D.J., Peters S.E., Hopkin J.M.;
"The cloning and characterization of the arom gene of Pneumocystis carinii.";
J. Gen. Microbiol. 139:2901-2914(1993).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L18918; AAA17839.1; -; Unassigned_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR T30832; T30832.
3D structure databases
HSSP P07547; 1NVE. [HSSP ENTRY / PDB]
ModBase Q12659.
Family and domain databases
InterPro IPR013785; Aldolase_TIM.
IPR002658; DHQ_synth_AroB.
IPR016037; DHQ_synth_AroB_sub.
IPR001381; DHquinase_I.
IPR001986; EPSP_synthase_core.
IPR006264; EPSP_synthase_subgroup.
IPR008289; Pentafunct_AroM.
IPR010110; Shik_DHase_AROM.
IPR000623; Shik_kinase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:3.65.10.10; EPSP_synthase; 1.
PANTHER PTHR21090:SF1; DHQ_synth_AroB; 1.
Pfam PF01761; DHQ_synthase; 1.
PF01487; DHquinase_I; 1.
PF00275; EPSP_synthase; 1.
PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
PF01202; SKI; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000514; Pentafunct_AroM; 1.
PRINTS PR01100; SHIKIMTKNASE.
ProDom PD005337; DHquinase_I; 1.
PD001867; EPSP_synth; 2.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01356; aroA; 1.
TIGR01357; aroB; 1.
TIGR01093; aroD; 1.
TIGR01809; Shik-DH-AROM; 1.
PROSITE PS01028; DEHYDROQUINASE_I; 1.
PS00104; EPSP_SYNTHASE_1; 1.
PS00885; EPSP_SYNTHASE_2; 1.
PS01128; SHIKIMATE_KINASE; 1.
BLOCKS Q12659.
Other
ProtoNet Q12659.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Aromatic amino acid biosynthesis; ATP-binding; Cytoplasm; Kinase; Lyase; Multifunctional enzyme; NADP; Nucleotide-binding; Oxidoreductase; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   1581  1581     Pentafunctional AROM polypeptide. PRO_0000140860
NP_BIND   875    882  8     ATP (Potential). 
REGION   1    383  383     3-dehydroquinate synthase. 
REGION   395    840  446     EPSP synthase. 
REGION   867   1042  176     Shikimate kinase. 
REGION   1043   1284  242     3-dehydroquinase. 
REGION   1297   1581  285     Shikimate dehydrogenase. 
ACT_SITE   827    827        Potential. 
ACT_SITE   1189   1189        Proton acceptor (By similarity). 
ACT_SITE   1217   1217        Schiff-base intermediate with substrate (By similarity). 
Sequence information
Length: 1581 AA [This is the length of the unprocessed precursor] Molecular weight: 178045 Da [This is the MW of the unprocessed precursor] CRC64: 417A84356061170F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKEIIKLSIL GKDSIHIGLH LWPHITNELF TCIFSPTYVI ITDSNIETLY IPSFKTYFIS 

        70         80         90        100        110        120 
MAKQRSINSR LLFFTIPPGE KSKSRKTKAL IEDWLLSEKC TRDTVIIAIG GGVIGDLVGY 

       130        140        150        160        170        180 
VSATFMRGVR FIQIPTTLLA MVDSSIGGKN SINTSYGKNA IGTIWQPERI FIDFTFLETL 

       190        200        210        220        230        240 
TEKEFINGIA ELIKTIIIWD ESEFASLENI SEKIAKTVRS MSLTSNKHSK FNEIIKDLKR 

       250        260        270        280        290        300 
YIISSIKIKA HIVSIDEKEK DLRTLLNFGH SIGHAIETVL APYILHGESI SIGMVKEAEL 

       310        320        330        340        350        360 
SRHLGILNPN VVSRLIKCLN TWGLPTSFKD RRFKEVILGK KHLIEDILEI MSIDKKNDSN 

       370        380        390        400        410        420 
NKKIVLLSAI GKTYEKKASS VSDDDIRTIL SQNILLYGIP LNAFQKHTTI TLPGSKSISN 

       430        440        450        460        470        480 
RALILASLSN GICYLKNFLH SDDTYYMLSA LEKLNAAEFK WEQDGDVLVV KGKSGYLENP 

       490        500        510        520        530        540 
QMELYLGNSG TTARFLTSIC TLVQPNSREN HLILTGSNRM KQRPIGPLVD ALKNNGCCIE 

       550        560        570        580        590        600 
YLELENCLPL LIKPKEIGLY GGNINLSATV SSQYVSSILM CSPYAKTQVT LSLIGGKPIS 

       610        620        630        640        650        660 
QPYIDMTISM MSSFGIKVTR SHSKENTYYI PKGCYTCPSE YIIEGDATSA TYPLAIAAIT 

       670        680        690        700        710        720 
GGSCTISNVG SASLQGDSKF SEYILKPMGC EVVQSPTTTY IKGPPKGKLK SLGSINMESM 

       730        740        750        760        770        780 
TDTFLTAAVL ASVAYEESKP YVTKITGISN QRIKECNRIN AMVCELKKFG IEAGELPDGI 

       790        800        810        820        830        840 
YVKALNTSNL PYSVEGINCY NDHRIAMSFS VLACISSKPT TILDKACVNK TWPYWWDILN 

       850        860        870        880        890        900 
STFKVQMKGI EFDLNPTINS SILHHPSECT IFLIGMRGAG KTTLGQLAAN FLGREFIDLD 

       910        920        930        940        950        960 
SIIEEDIKTT ILEFIQKYSW DVFRRKELHF LKTLLTEKKE NYIISCGGGI IETEEARDLL 

       970        980        990       1000       1010       1020 
ISYIEANGIV IHIHRNIQDI IKYLNTDKTR APYQDNIMHV WERRKRWYNL CSSHQFHMTS 

      1030       1040       1050       1060       1070       1080 
TDPTEFKKNI PLNLKSSFNN FLRTITGKNN IFSLILKKKR SYFLSLAFSD LENIFSLLDI 

      1090       1100       1110       1120       1130       1140 
ITAGCDAIEI RIDLFQKPEE IDKYPSLEYI AEKIFLLRQK TSLPLIYTLR TTNHGGSFLS 

      1150       1160       1170       1180       1190       1200 
SEKKLAKEYI LHGAKWGFEF LDIELDIASE LFKTINNSWP YTKIIASYHN IEKPISCDDF 

      1210       1220       1230       1240       1250       1260 
EWIQKYKEAQ HYGHIIKLVG TSSSIEDNFF LEEFKSKFIN KKVPSIIINT GIKGQLSRIM 

      1270       1280       1290       1300       1310       1320 
NTFMTPVTHP SLPSKIAPGQ LSIKEINTAL HIMGLLPEKK YFLFGKPIKH SQSPNIHNLG 

      1330       1340       1350       1360       1370       1380 
FEILGLPYKY QLFETDSISE LKEILHLEEF GGASVTIPLK TNISILLDEI SDHAALIGSV 

      1390       1400       1410       1420       1430       1440 
NTITRTYNNG QYILKGENTD WQGIIKAIKN FNKFEKSFEN FSGFIIGAGG ASRAAIYALL 

      1450       1460       1470       1480       1490       1500 
SLGISPIYLI NRSKDKLNKL YHFFNTNHII PITEYHELNN INFDIRIGIS TIPTDNPIDP 

      1510       1520       1530       1540       1550       1560 
SVLEIAKIFF NLKRKSSEGI FLDMAYGSNT TDLTIIAKAC NWKIIHGLEI LLEQGSEQFL 

      1570       1580 
LWTETYIPYN QVKYAILGPN K
Q12659 in FASTA format

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