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UniProtKB/Swiss-Prot entry Q12XM4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G3P_METBU
Primary accession number Q12XM4
Secondary accession numbers None
Integrated into Swiss-Prot on September 11, 2007
Sequence was last modified on August 22, 2006 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 21)
Name and origin of the protein
Protein name Glyceraldehyde-3-phosphate dehydrogenase
Synonyms GAPDH
EC 1.2.1.59
NAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase
Gene name
Name: gap
OrderedLocusNames: Mbur_0851
From
Methanococcoides burtonii (strain DSM 6242) [TaxID: 259564] [HAMAP proteome]
Taxonomy Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales; Methanosarcinaceae; Methanococcoides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Kadner K., Aerts A., Dehal P., Pitluck S., Martinez M., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Franzmann P., Thomas T., Saunders N., Cavicchioli R., Sowers K., Richardson P.;
"Complete sequence of Methanococcoides burtonii DSM 6242.";
Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000300; ABE51802.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_565552.1; -.
3D structure databases
ModBase Q12XM4.
Enzyme and pathway databases
BioCyc MBUR259564:MBUR_0851-MON; -.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from HAMAP).
GO:0004365; Molecular function: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00559; -; 1.
PBIL [Tree]
InterPro IPR000173; GlycerAld_3-P_DHase.
IPR006436; Glyceraldehyde-3-P_DHase_2_arc.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR10836; GAP_DH; 1.
Pfam PF02800; Gp_dh_C; 1.
PF00044; Gp_dh_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000149; GAP_DH; 1.
ProDom PD007761; GAPDH_like; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR01546; GAPDH-II_archae; 1.
PROSITE PS00071; GAPDH; 1.
BLOCKS Q12XM4.
Genome annotation databases
GeneID 3996756; -.
GenomeReviews CP000300_GR; Mbur_0851.
KEGG mbu:Mbur_0851; -.
NMPDR fig|259564.8.peg.809; -.
Phylogenomic databases
HOGENOM Q12XM4; -.
Genome annotation databases
CMR Q12XM4; Mbur_0851.
Other
ProtoNet Q12XM4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Cytoplasm; Glycolysis; NAD; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   335  335     Glyceraldehyde-3-phosphate dehydrogenase. PRO_0000300972
NP_BIND   13    14  2     NAD (By similarity). 
REGION   140   142  3     Glyceraldehyde 3-phosphate binding (By similarity). 
REGION   195   196  2     Glyceraldehyde 3-phosphate binding (By similarity). 
ACT_SITE   141   141        Nucleophile (By similarity). 
BINDING   111   111        NAD; via amide nitrogen (By similarity). 
BINDING   169   169        NAD (By similarity). 
BINDING   300   300        NAD; via carbonyl oxygen (By similarity). 
Sequence information
Length: 335 AA [This is the length of the unprocessed precursor] Molecular weight: 36576 Da [This is the MW of the unprocessed precursor] CRC64: 3CD1D29A2589F594 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MTKVKVAING YGTIGKRVAD AVALQDDMEI IGIAKTRPNF ETVMAKDKGF NVYTLADRVG 

        70         80         90        100        110        120 
AMEKEGIEVS GTVEEMIKAA DVVVDCTPGK VGATNKDLYE KAGIKAIWQG GEAHTLTGCS 

       130        140        150        160        170        180 
FNAETNYDEA LGKDFVRVVS CNTTGLCRVL SPLDKEFGVK KARVTLLRRA ADPGDIKTGP 

       190        200        210        220        230        240 
INAIVPNPIK LPSHHGPDVK TVIPNIDIAT TAVKLPTTLM HLHTINLELE KECTAEDVES 

       250        260        270        280        290        300 
VLAEQSRVRF VGQGITSTAE IMELAKDLGR SRGDMWENCI WNESITMYEG ELYFFQAIHQ 

       310        320        330 
ESDVIPENID AIRAMMELES DASRSIEITN KTMGI
Q12XM4 in FASTA format

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