[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
Nezu J.;
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases.
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
DOI=10.1038/ng0198-38; PubMed=9425897 [NCBI, ExPASy, EBI, Israel, Japan]
Jenne D.E.,
Reimann H.,
Nezu J.,
Friedl W.,
Loff S.,
Jeschke R.,
Mueller O.,
Back W.,
Zimmer M.;
"Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.";
Nat. Genet. 18:38-43(1998).
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[3]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9537235 [NCBI, ExPASy, EBI, Israel, Japan]
Bignell G.R.,
Barfoot R.,
Seal S.,
Collins N.,
Warren W.,
Stratton M.R.;
"Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer.";
Cancer Res. 58:1384-1386(1998).
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung, and Uterus;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[5]
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IDENTIFICATION AS A RENAL CANCER ANTIGEN.
TISSUE=Renal cell carcinoma;
DOI=10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5; PubMed=10508479 [NCBI, ExPASy, EBI, Israel, Japan]
Scanlan M.J.,
Gordan J.D.,
Williamson B.,
Stockert E.,
Bander N.H.,
Jongeneel C.V.,
Gure A.O.,
Jaeger D.,
Jaeger E.,
Knuth A.,
Chen Y.-T.,
Old L.J.;
"Antigens recognized by autologous antibody in patients with renal-cell carcinoma.";
Int. J. Cancer 83:456-464(1999).
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[6]
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IDENTIFICATION IN A TERNARY COMPLEX COMPOSED OF SMAD4 AND STK11IP, AND INTERACTS WITH SMAD4 AND STK11IP.
DOI=10.1093/hmg/10.25.2869; PubMed=11741830 [NCBI, ExPASy, EBI, Israel, Japan]
Smith D.P.,
Rayter S.I.,
Niederlander C.,
Spicer J.,
Jones C.M.,
Ashworth A.;
"LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1.";
Hum. Mol. Genet. 10:2869-2877(2001).
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[7]
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FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH STRAD, AUTOPHOSPHORYLATION AT THR-336 AND THR-363, AND MUTAGENESIS OF ASP-176.
DOI=10.1093/emboj/cdg292; PubMed=12805220 [NCBI, ExPASy, EBI, Israel, Japan]
Baas A.F.,
Boudeau J.,
Sapkota G.P.,
Smit L.,
Medema R.,
Morrice N.A.,
Alessi D.R.,
Clevers H.C.;
"Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD.";
EMBO J. 22:3062-3072(2003).
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[8]
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FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF ASP-194, AND INTERACTION WITH STRAD AND CAB39.
DOI=10.1093/emboj/cdg490; PubMed=14517248 [NCBI, ExPASy, EBI, Israel, Japan]
Boudeau J.,
Baas A.F.,
Deak M.,
Morrice N.A.,
Kieloch A.,
Schutkowski M.,
Prescott A.R.,
Clevers H.C.,
Alessi D.R.;
"MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.";
EMBO J. 22:5102-5114(2003).
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[9]
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VARIANT TESTICULAR TUMORS ASP-163.
PubMed=9605748 [NCBI, ExPASy, EBI, Israel, Japan]
Avizienyte E.,
Roth S.,
Loukola A.,
Hemminki A.,
Lothe R.A.,
Stenwig A.E.,
Fossaa S.D.,
Salovaara R.,
Aaltonen L.A.;
"Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.";
Cancer Res. 58:2087-2090(1998).
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[10]
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VARIANT PJS ASN-247 DEL.
DOI=10.1007/s004390050801; PubMed=9760200 [NCBI, ExPASy, EBI, Israel, Japan]
Nakagawa H.,
Koyama K.,
Miyoshi Y.,
Ando H.,
Baba S.,
Watatani M.,
Yasutomi M.,
Matsuura N.,
Monden M.,
Nakamura Y.;
"Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.";
Hum. Genet. 103:168-172(1998).
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[11]
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VARIANTS PJS PRO-67 AND 303-ILE--GLN-306 DELINS ASN.
DOI=10.1038/34432; PubMed=9428765 [NCBI, ExPASy, EBI, Israel, Japan]
Hemminki A.,
Markie D.,
Tomlinson I.,
Avizienyte E.,
Roth S.,
Loukola A.,
Bignell G.,
Warren W.,
Aminoff M.,
Hoeglund P.,
Jaervinen H.,
Kristo P.,
Pelin K.,
Ridanpaeae M.,
Salovaara R.,
Toro T.,
Bodmer W.,
Olschwang S.,
Olsen A.S., ![]()
Stratton M.R.,
de la Chapelle A.,
Aaltonen L.A.;
"A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.";
Nature 391:184-187(1998).
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[12]
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VARIANTS PJS 162-ASN--MET-164; ASN-194 AND LYS-297.
DOI=10.1002/(SICI)1098-1004(1999)13:6<476::AID-HUMU7>3.3.CO;2-U; PubMed=10408777 [NCBI, ExPASy, EBI, Israel, Japan]
Westerman A.M.,
Entius M.M.,
Boor P.P.C.,
Koole R.,
de Baar E.,
Offerhaus G.J.A.,
Lubinski J.,
Lindhout D.,
Halley D.J.J.,
de Rooij F.W.M.,
Wilson J.H.P.;
"Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.";
Hum. Mutat. 13:476-481(1999).
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[13]
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CHARACTERIZATION OF VARIANT TESTICULAR TUMORS ASP-163.
DOI=10.1093/hmg/8.1.45; PubMed=9887330 [NCBI, ExPASy, EBI, Israel, Japan]
Ylikorkala A.,
Avizienyte E.,
Tomlinson I.P.,
Tiainen M.,
Roth S.,
Loukola A.,
Hemminki A.,
Johansson M.,
Sistonen P.,
Markie D.,
Neale K.,
Phillips R.,
Zauber P.,
Twama T.,
Sampson J.,
Jaervinen H.,
Maekelae T.P.,
Aaltonen L.A.;
"Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.";
Hum. Mol. Genet. 8:45-51(1999).
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[14]
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VARIANTS MELANOMA ASP-49 AND ARG-135.
DOI=10.1046/j.1523-1747.1999.00551.x; PubMed=10201537 [NCBI, ExPASy, EBI, Israel, Japan]
Rowan A.,
Bataille V.,
MacKie R.,
Healy E.,
Bicknell D.,
Bodmer W.,
Tomlinson I.;
"Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.";
J. Invest. Dermatol. 112:509-511(1999).
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[15]
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VARIANT MELANOMA TYR-194.
DOI=10.1038/sj.onc.1202486; PubMed=10208439 [NCBI, ExPASy, EBI, Israel, Japan]
Guldberg P.,
thor Straten P.,
Ahrenkiel V.,
Seremet T.,
Kirkin A.F.,
Zeuthen J.;
"Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.";
Oncogene 18:1777-1780(1999).
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[16]
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VARIANTS PJS CYS-239 AND SER-315.
DOI=10.1034/j.1399-0004.2002.620405.x; PubMed=12372054 [NCBI, ExPASy, EBI, Israel, Japan]
Scott R.J.,
Crooks R.,
Meldrum C.J.,
Thomas L.,
Smith C.J.A.,
Mowat D.,
McPhillips M.,
Spigelman A.D.;
"Mutation analysis of the STK11/LKB1 gene and clinical characteristics of an Australian series of Peutz-Jeghers syndrome patients.";
Clin. Genet. 62:282-287(2002).
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[17]
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VARIANT [LARGE SCALE ANALYSIS] LYS-87.
DOI=10.1038/nature05610; PubMed=17344846 [NCBI, ExPASy, EBI, Israel, Japan]
Greenman C.,
Stephens P.,
Smith R.,
Dalgliesh G.L.,
Hunter C.,
Bignell G.,
Davies H.,
Teague J.,
Butler A.,
Stevens C.,
Edkins S.,
O'Meara S.,
Vastrik I.,
Schmidt E.E.,
Avis T.,
Barthorpe S.,
Bhamra G.,
Buck G.,
Choudhury B., ![]()
Clements J.,
Cole J.,
Dicks E.,
Forbes S.,
Gray K.,
Halliday K.,
Harrison R.,
Hills K.,
Hinton J.,
Jenkinson A.,
Jones D.,
Menzies A.,
Mironenko T.,
Perry J.,
Raine K.,
Richardson D.,
Shepherd R.,
Small A.,
Tofts C.,
Varian J.,
Webb T.,
West S.,
Widaa S.,
Yates A.,
Cahill D.P.,
Louis D.N.,
Goldstraw P.,
Nicholson A.G.,
Brasseur F.,
Looijenga L.,
Weber B.L.,
Chiew Y.-E.,
DeFazio A.,
Greaves M.F.,
Green A.R.,
Campbell P.,
Birney E.,
Easton D.F.,
Chenevix-Trench G.,
Tan M.-H.,
Khoo S.K.,
Teh B.T.,
Yuen S.T.,
Leung S.Y.,
Wooster R.,
Futreal P.A.,
Stratton M.R.;
"Patterns of somatic mutation in human cancer genomes.";
Nature 446:153-158(2007).
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