NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pbio.0040188; PubMed=16729848 [NCBI, ExPASy, EBI, Israel, Japan]
Wu D., Daugherty S.C., Van Aken S.E., Pai G.H., Watkins K.L., Khouri H., Tallon L.J., Zaborsky J.M., Dunbar H.E., Tran P.L., Moran N.A., Eisen J.A.;
"Metabolic complementarity and genomics of the dual bacterial symbiosis of sharpshooters.";
PLoS Biol. 4:1079-1092(2006).

Comments

CATALYTIC ACTIVITY: (S)-dihydroorotate + O₂ = orotate + H₂O₂.
COFACTOR: Binds 1 FMN per subunit (By similarity).
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 4/6 .
SUBUNIT: Homodimer (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity).
SIMILARITY: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000238; ABF14134.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_588852.1; -.

3D structure databases

SMR

Q1LT62; 1-336.

ModBase

Q1LT62.

Ontologies

GO:0005886;	Cellular component: plasma membrane (inferred from electronic annotation from HAMAP).
GO:0004158;	Molecular function: dihydroorotate oxidase activity (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00225; -; 1.
PBIL [Tree]

InterPro

IPR013785; Aldolase_TIM.
IPR012135; DHO_DHase_1_2.
IPR005719; DHO_DHase_2.
IPR001295; Dihydroorotate_DHase_core.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF01180; DHO_dh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000164; DHO_oxidase; 1.

TIGRFAMs

TIGR01036; pyrD_sub2; 1.

PROSITE

PS00911; DHODEHASE_1; 1.
PS00912; DHODEHASE_2; 1.

BLOCKS

Q1LT62.

Genome annotation databases

GeneID

4056320; -.

GenomeReviews

CP000238_GR; BCI_0409.

KEGG

bci:BCI_0409; -.

Phylogenomic databases

HOGENOM

Q1LT62; -.

Genome annotation databases

CMR

Q1LT62; BCI_0409.

Other

ProtoNet

Q1LT62.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cell membrane; Complete proteome; Flavoprotein; FMN; Membrane; Oxidoreductase; Pyrimidine biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 336`	`336`	`Dihydroorotate dehydrogenase.`	`PRO_1000024153`
`ACT_SITE`	`175 175`		`Nucleophile (By similarity).`

Sequence information

Length: 336 AA [This is the length of the unprocessed precursor]

Molecular weight: 36873 Da [This is the MW of the unprocessed precursor]

CRC64: B00B0E763B82D580 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLYPLIRQFL FQLDPEKAHE LTIQQLKRIA GTPLEYLVRQ SVPTKAVTCM GIAFKNPLGL 

        70         80         90        100        110        120 
AAGLDKNGEC IDALGAMGFG FIEVGTVTPH AQIGNEKPRL FRLTKAYGLI NRMGFNNKGV 

       130        140        150        160        170        180 
DNLVNNIQKS HFGGVLGINI GKNKDTPIEQ GKDDYLICME KVYPYANYIA VNISSPNTPQ 

       190        200        210        220        230        240 
LTTLQSGEIL DDLLRAIKDK QAKLQEYHHK YVPIAVKITP DMTESELIQM ADLLVQHKID 

       250        260        270        280        290        300 
GIIATNTTTS RELVHGLDHS SQSGGLSGRP LQLMSTEVIR ILSSKLQGKL PIIGVGGIDS 

       310        320        330 
LISAREKMAA GATLIQIYSS FIFHGPRLIK DIISDL

Q1LT62 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools