NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pgen.0020076; PubMed=16703114 [NCBI, ExPASy, EBI, Israel, Japan]
Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C., Fournier P.-E., Claverie J.-M., Raoult D.;
"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens.";
PLoS Genet. 2:733-744(2006).

Comments

FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000087; ABE05180.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_538269.1; -.

3D structure databases

ModBase

Q1RHI4.

Enzyme and pathway databases

BioCyc

RBEL336407:RBE_1099-MON; -.

Family and domain databases

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.

BLOCKS

Q1RHI4.

Genome annotation databases

GeneID

3995010; -.

GenomeReviews

CP000087_GR; RBE_1099.

KEGG

rbe:RBE_1099; -.

Phylogenomic databases

HOGENOM

Q1RHI4; -.

Genome annotation databases

CMR

Q1RHI4; RBE_1099.

Other

ProtoNet

Q1RHI4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Glycolysis; Oxidoreductase; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 927`	`927`		`2-oxoglutarate dehydrogenase E1 component.`	`PRO_0000288749`

Sequence information

Length: 927 AA [This is the length of the unprocessed precursor]

Molecular weight: 103677 Da [This is the MW of the unprocessed precursor]

CRC64: AAD6B2E0CEF8304E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MEENLKKTGF LFGGNAVFIE ELYKQYLENP ASVDQTWQEF FSSVKDSNQL LNKSTAKIIL 

        70         80         90        100        110        120 
KAAATEESKT SENPVSTTNN FNVGAMIKNY RKYAHYLAKL DPLGLEVTKT KEDLKLSIEN 

       130        140        150        160        170        180 
FGFTNDQLSK VIEHKFLEKT YNLGELVNFL DKTYAGSIGV EFEQVENEEE KNWLYSKLES 

       190        200        210        220        230        240 
GVISFSSEEK KNILNDLVEV EGFEQYLHTK FPGAKRFSVE GGDASIVAMN KAIDLSLHQG 

       250        260        270        280        290        300 
VEEIVIGMAH RGRLNTLTKV VGKPYRAVIA GFISGSVFPD ELNVSGDVKY HLGYSSDRVV 

       310        320        330        340        350        360 
GDKKIHLSLA DNPSHLEAVN PIFAGKVRAK QDMLKDNKRS KVKAILVHGD AAFCGQGVVA 

       370        380        390        400        410        420 
ESLSMSPLAA YNIGGVLHFV INNQLGFTAN AADTRASRYS TEFAKIIAVP ILHVNGDDIE 

       430        440        450        460        470        480 
AVLKATNIAV EYRQKFGKDV IVEIICYRKY GHNEGDEPMY TQGKMYNIIK SKLTPGNIYA 

       490        500        510        520        530        540 
NELVKSGVID NNYFAKLKEQ FKAKLDKEYE QAKNYKQEAH FLGGLWQGIT RTRTQVAVTG 

       550        560        570        580        590        600 
VDKKTLQSLG TKLCEMPKDF AVNPKLVKLF DARKAALTAD QPIDWATAEQ LAFASLLTSG 

       610        620        630        640        650        660 
TNIRLTGQDC GRGTFSHRHS VLHNQVDDTT YIPLNNLSKE QATYEVADSN LSEYAVLGFE 

       670        680        690        700        710        720 
YGYSLANPKN LVLWEAQFGD FANGAQIIFD QFISSSETKW LRMSGLVVLL PHGFEGQGPE 

       730        740        750        760        770        780 
HSSARLERFL QLAAEDNMYV TYPTTPASIF HLLRRQIIDN VRKPLIVMSP KSLLRHKNVV 

       790        800        810        820        830        840 
SKLDELGSNT TFLPVLDEVN KLEASNITKV ILCSGKVYYD LFEMRGSNSS IAIIRLEQLY 

       850        860        870        880        890        900 
PFEKKVVVEL LKKYNKASEF IWCQEEPMNM GAWRYITSHL NNALKEAGIN NEFKYIGREE 

       910        920 
SASPAVGSLQ AHNKQQEKLL KEALGVK

Q1RHI4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools