NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 10-31.
STRAIN=UC;
DOI=10.1016/0166-6851(95)00023-T; PubMed=7630384 [NCBI, ExPASy, EBI, Israel, Japan]
Bringaud F., Peris M., Zen K.H., Simpson L.;
"Characterization of two nuclear-encoded protein components of mitochondrial ribonucleoprotein complexes from Leishmania tarentolae.";
Mol. Biochem. Parasitol. 71:65-79(1995).

Comments

FUNCTION: Could have a RNA-binding activity in addition of its catalytic role.
CATALYTIC ACTIVITY: An aldehyde + NAD⁺ + H₂O = an acid + NADH.
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2 .
SUBCELLULAR LOCATION: Mitochondrion.
SIMILARITY: Belongs to the aldehyde dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

Z31698; CAA83503.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

PIR

S43184; S43184.

3D structure databases

HSSP

P05091; 1O01. [HSSP ENTRY / PDB]

ModBase

Q25417.

Family and domain databases

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Direct protein sequencing; Mitochondrion; NAD; Oxidoreductase; RNA-binding; Transit peptide.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`TRANSIT`	`1 9`	`9`	`Mitochondrion.`
`CHAIN`	`10 498`	`489`	`Aldehyde dehydrogenase, mitochondrial.`	`PRO_0000007171`
`NP_BIND`	`242 247`	`6`	`NAD (By similarity).`
`ACT_SITE`	`265 265`		`Proton acceptor (By similarity).`
`ACT_SITE`	`299 299`		`Nucleophile (By similarity).`
`SITE`	`166 166`	`1`	`Transition state stabilizer (By similarity).`

Sequence information

Length: 498 AA [This is the length of the unprocessed precursor]

Molecular weight: 54252 Da [This is the MW of the unprocessed precursor]

CRC64: 618D55F6ED5547EC [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLRATLARLE MAPKVTHIQE KLLINGKFVP AVSGKTFEVV NPADEKVIAN VAEAEKADVD 

        70         80         90        100        110        120 
LAVKAARHAF ESFRMTDCQW RRNLMLRLAD ILEKNSKEMA ALESLDNGKP YEVALNVDVA 

       130        140        150        160        170        180 
LSVECFRYCA GLADKVNGTV PPRSGNFLGI VKRQPIGVCG QIIPWNFPLL MAAFKLSPAL 

       190        200        210        220        230        240 
AMGNTVVLKP AEQTPLTAVR LGEMVMEAGY PDGVLNILPG FGATAGSEIA RHMDVDKIAF 

       250        260        270        280        290        300 
TGSTAVGHQV MQMAAETNLK KVSLELGGKS ALIVCEDADL EEAAEVATTR VYFNTGQVCT 

       310        320        330        340        350        360 
ASSRIYVHES VYDEFVSRLR KNAEARKVGP GNDTGNNMGP LVSKKQHERV LGYIEDGVKA 

       370        380        390        400        410        420 
GATVVTGGKK IGDKGYFVQP TIFSDVKEDM RICKEEIFGP VTCVMKYKDM DEVVKRANDS 

       430        440        450        460        470        480 
IYGLAAGICT RSMDTALRYS TYLNAGTVWV NTWNNFCPSM PFGGFKQSGI GRELGKEVVD 

       490 
MYTEPKAIHF ASRSIVKP

Q25417 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools