ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry Q27772

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name C1TC_SPOFR
Primary accession number Q27772
Secondary accession numbers None
Integrated into Swiss-Prot on January 16, 2004
Sequence was last modified on January 16, 2004 (Sequence version 3)
Annotations were last modified on    September 2, 2008 (Entry version 55)
Name and origin of the protein
Protein name C-1-tetrahydrofolate synthase, cytoplasmic
Synonym C1-THF synthase
Includes Methylenetetrahydrofolate dehydrogenase
     (EC 1.5.1.5)
Methenyltetrahydrofolate cyclohydrolase
     (EC 3.5.4.9)
Formyltetrahydrofolate synthetase
     (EC 6.3.4.3)
Gene name None
From
Spodoptera frugiperda (Fall armyworm) [TaxID: 7108] 
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; Noctuidae; Amphipyrinae; Spodoptera.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Ovary;
DOI=10.1016/0167-4781(95)00004-Z; PubMed=7893749 [NCBI, ExPASy, EBI, Israel, Japan]
Tremblay G.B., MacKenzie R.E.;
"Primary structure of a folate-dependent trifunctional enzyme from Spodoptera frugiperda.";
Biochim. Biophys. Acta 1261:129-133(1995).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
L36189; AAA74302.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR S53523; S53523.
3D structure databases
HSSP P11586; 1A4I. [HSSP ENTRY / PDB]
ModBase Q27772.
Family and domain databases
InterPro IPR000559; Fmtethyd_synth.
IPR016040; NAD(P)-bd.
IPR000672; THF_DHase/CycOHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01268; FTHFS; 1.
PF00763; THF_DHG_CYH; 1.
PF02882; THF_DHG_CYH_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00085; THFDHDRGNASE.
ProDom PD002300; THFDhg/Cyc_hydro; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00721; FTHFS_1; 1.
PS00722; FTHFS_2; 1.
PS00766; THF_DHG_CYH_1; 1.
PS00767; THF_DHG_CYH_2; 1.
BLOCKS Q27772.
Other
ProtoNet Q27772.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; ATP-binding; Cytoplasm; Histidine biosynthesis; Hydrolase; Ligase; Methionine biosynthesis; Multifunctional enzyme; NADP; Nucleotide-binding; One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   933  933     C-1-tetrahydrofolate synthase, cytoplasmic. PRO_0000199325
NP_BIND   170   172  3     NADP (By similarity). 
NP_BIND   378   385  8     ATP (By similarity). 
REGION   1   303  303     Methylenetetrahydrofolate dehydrogenase and cyclohydrolase. 
REGION   51    55  5     Substrate binding (By similarity). 
REGION   98   100  3     Substrate binding (By similarity). 
REGION   270   274  5     Substrate binding (By similarity). 
REGION   304   933  630     Formyltetrahydrofolate synthetase. 
BINDING   195   195        NADP (By similarity). 
Sequence information
Length: 933 AA [This is the length of the unprocessed precursor] Molecular weight: 100618 Da [This is the MW of the unprocessed precursor] CRC64: 55C3FA820C1A55CB [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MWEPQGSLDP VLESIENELR DQVAEARSRW AGFDARLAIV QVGGREDSNV YIRMKLRAAE 

        70         80         90        100        110        120 
NIGITAEHIQ LPRDITETEL LANITSLNES PYVHGIIVQM PLDSVHPIDS HAITDAVSPD 

       130        140        150        160        170        180 
KDVDGLNTIN EGRVRVGDLS GFIPCTPAGC VELIKRTGVT IAGKNVVVLG RSRIVGTPVS 

       190        200        210        220        230        240 
ELLKWEHATV TVCHSKTKNL SEITKTADIL VVAIGRGEMV RGSWIKPGAV VIDCGINPIS 

       250        260        270        280        290        300 
DPTKKSGQRL VGDVAYEEAV QVASHVTPVP GGVGPMTVAM LMRNTVQAAR RQLDRLLAPT 

       310        320        330        340        350        360 
WPLRPLRITP LSPPPSDIVI ARSQKPKDIS ELAHEIGLFS NEVSQYGRTK AKISLSVLDR 

       370        380        390        400        410        420 
MRNQQGAKYI VVAGITPTPL GEGKSTTLLG LVQALSAHRG RNSFAVMRQP SQGPTFGVKG 

       430        440        450        460        470        480 
GAAGGGYSQV IPMEEFNLHL TGDIHAGTAA NNLLAAQMDA RIFHELTQKD GPLFDRLVPK 

       490        500        510        520        530        540 
IKGVRKFSPI QLRRLKRLGI TKTDPDTLTE GEKSKFARLN IDTSKIMWNR VVDLNDRYLR 

       550        560        570        580        590        600 
KITVGQSPTE KGFTRETAFD ISVASEIMAI LALGRDVEDI KERLANMVVA LDKSGNPVTA 

       610        620        630        640        650        660 
DDLGMTGALL VLLRDAFEPT LMQSLEGTPV LVHTGPFANI RHGCSSILAD KIAMKLAGEN 

       670        680        690        700        710        720 
GYVATEAGFG SDIGMEKFFD IKCRASGDTP HCAVIVSTVR ALKMHGGGPP VSAGMPLNDV 

       730        740        750        760        770        780 
YVQENLELLS KGLCNLGKHI SNGNKFGVPV VVAINKHGND TPAELNLVKE FAVKNGAFRA 

       790        800        810        820        830        840 
VLCDHWAKGG LGALELADAV IEACDSKSKF DFLYPLQLSI QEKIQIIAKE MYGAGQVEYT 

       850        860        870        880        890        900 
DEVLEKIKTF TDMGYDKFPI CMAKTSNSLT GDPAVKGAPT GFTLKINGIF ASVGAGFVVP 

       910        920        930 
MVGEISKMPG LPTRPSIYDI DLNTKTGEIE GLF
Q27772 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ca flag CBR Canada Mirror sites: Australia Brazil China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!