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UniProtKB/Swiss-Prot entry Q28007

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DPYD_BOVIN
Primary accession number Q28007
Secondary accession number Q9TRV4
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1997 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 60)
Name and origin of the protein
Protein name Dihydropyrimidine dehydrogenase [NADP+]
Synonyms DHPDHase
DPD
EC 1.3.1.2
Dihydrouracil dehydrogenase
Dihydrothymine dehydrogenase
Gene name
Name: DPYD
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8912928 [NCBI, ExPASy, EBI, Israel, Japan]
Albin N., Johnson M.R., Diasio R.B.;
"cDNA cloning of bovine liver dihydropyrimidine dehydrogenase.";
DNA Seq. 6:243-250(1996).
[2]
 PROTEIN SEQUENCE OF 668-678, AND ENZYME REGULATION.
TISSUE=Liver;
PubMed=1939061 [NCBI, ExPASy, EBI, Israel, Japan]
Porter D.J.T., Chestnut W.G., Taylor L.C.E., Merrill B.M., Spector T.;
"Inactivation of dihydropyrimidine dehydrogenase by 5-iodouracil.";
J. Biol. Chem. 266:19988-19994(1991).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
U20981; AAB40985.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A44626; A44626.
RefSeq NP_776466.1; -.
UniGene Bt.97060
3D structure databases
HSSP Q28943; 1GTE. [HSSP ENTRY / PDB]
SMR Q28007; 2-1017.
ModBase Q28007.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from sequence or structural similarity from UniProtKB).
GO:0017113; Molecular function: dihydropyrimidine dehydrogenase (NADP+) activity (inferred from direct assay from UniProtKB).
GO:0050661; Molecular function: NADP binding (inferred from direct assay from UniProtKB).
GO:0042803; Molecular function: protein homodimerization activity (inferred from direct assay from UniProtKB).
GO:0006214; Biological process: thymidine catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0006212; Biological process: uracil catabolic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR001450; 4Fe4S_Fe_S_bd.
IPR000759; Adrndx_reductase.
IPR013785; Aldolase_TIM.
IPR005720; DHO_DHase_1_core.
IPR001295; Dihydroorotate_DHase_core.
IPR013027; FAD_pyr_nucl-diS_OxRdtase.
IPR012285; Fum_reductase_C.
IPR016040; NAD(P)-bd.
IPR000103; Pyridine_nuc-diS_OxRdtase_2.
Graphical view of domain structure.
Gene3D G3DSA:3.20.20.70; Aldolase_TIM; 1.
G3DSA:1.10.1060.10; Fum_reductase_C; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF01180; DHO_dh; 1.
PF00037; Fer4; 1.
PF07992; Pyr_redox_2; 1.
Pfam graphical view of domain structure.
PRINTS PR00353; 4FE4SFRDOXIN.
PR00419; ADXRDTASE.
PR00368; FADPNR.
PR00469; PNDRDTASEII.
TIGRFAMs TIGR01037; pyrD_sub1_fam; 1.
PROSITE PS00198; 4FE4S_FER_1; 1.
PS51379; 4FE4S_FER_2; 3.
PROSITE graphical view of domain structure (profiles).
BLOCKS Q28007.
Genome annotation databases
Ensembl ENSBTAG00000031358; Bos taurus. [Contig view]
GeneID 281124; -.
KEGG bta:281124; -.
Phylogenomic databases
HOVERGEN Q28007; -.
Other
ProtoNet Q28007.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
4Fe-4S; Cytoplasm; Direct protein sequencing; FAD; Flavoprotein; FMN; Iron; Iron-sulfur; Metal-binding; NADP; Oxidoreductase; Phosphoprotein; Repeat.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   1025  1025     Dihydropyrimidine dehydrogenase [NADP+]. PRO_0000079996
DOMAIN   69    100  32     4Fe-4S ferredoxin-type 1. 
DOMAIN   944    976  33     4Fe-4S ferredoxin-type 2. 
DOMAIN   978   1007  30     4Fe-4S ferredoxin-type 3. 
METAL   953    953        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   956    956        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   959    959        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   963    963        Iron-sulfur 1 (4Fe-4S) (Potential). 
METAL   986    986        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   989    989        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   992    992        Iron-sulfur 2 (4Fe-4S) (Potential). 
METAL   996    996        Iron-sulfur 2 (4Fe-4S) (Potential). 
MOD_RES   577    577        Phosphoserine (By similarity). 
Sequence information
Length: 1025 AA [This is the length of the unprocessed precursor] Molecular weight: 111697 Da [This is the MW of the unprocessed precursor] CRC64: 5B55F93A06C47F4F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAPVLSKDVA DIESILALNP RTQSRATLRS TLAKKLDKKH WKRNPDKNCF NCEKLENNFD 

        70         80         90        100        110        120 
DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF ITSISNKNYY GAAKMIFSDN 

       130        140        150        160        170        180 
PLGLTCGMVC PTSDLCVGGC NLYATEEGPI NIGGLQQYAT EVFKAMNIPQ IRNPSLPPPE 

       190        200        210        220        230        240 
KMPEAYSAKI ALLGAGPASI SCASFLARLG YNDITIFEKQ EYVGGISTSE IPQFRLPYDV 

       250        260        270        280        290        300 
VNFEIELMKD LGVKIICGKS LSVNDITLST LKEEGYKAAF IGIGLPEPKK DHIFQGLTQD 

       310        320        330        340        350        360 
QGFYTSKDFL PLVAKSSKAG MCACHSPLLS IRGTVIVLGA GDTAFDCATS ALRCGARRVF 

       370        380        390        400        410        420 
IVFRKGFVNI RAVPEEVELA REEKCEFLPF LSPRKVIVKG GRIVAMQFVR TEQDETGKWN 

       430        440        450        460        470        480 
EDGDQIACLK ADVVISAFGS VLSDPKVKEA LSPIKFNRWD LPEVDPETMQ TSEPWVFAGG 

       490        500        510        520        530        540 
DVVGIANTTV EAVNDGKQAS WYIHRYIQSQ YGASVSAKPE LPLFYTPIDL VDISVEMAAL 

       550        560        570        580        590        600 
KFTNPFGLAS ATPTTSSSMI RRAFEAGWAF ALTKTFSLDK DIVTNVSPRI IRGTTSGPMY 

       610        620        630        640        650        660 
GPGQSSFLNI ELISEKTAAY WCQSVTELKA DFPDNIVIAS IMCSYNRNDW MELSRKAEAS 

       670        680        690        700        710        720 
GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ AVRIPFFAKL TPNVTDIVSI 

       730        740        750        760        770        780 
ARAAKEGGAN GVTATNTVSG LMGLKADGTP WPAVGREKRT TYGGVSGTAI RPIALRAVTT 

       790        800        810        820        830        840 
IARALPEFPI LATGGIDSAE SGLQFLHGGA SVLQVCSAIQ NQDFTIIQDY CTGLKALLYL 

       850        860        870        880        890        900 
KSIEELQDWD GQSPATKSHQ KGKPVPCIAE LVGKKLPSFG PYLEKCKKII AEEKLRLKKE 

       910        920        930        940        950        960 
NVTVLPLERN HFIPKKPIPS VKDVIGKALQ YLGTYGELNN TEQVVAVIDE EMCINCGKCY 

       970        980        990       1000       1010       1020 
MTCNDSGYQA IQFDPETHLP TVTDTCTGCT LCLSVCPIID CIKMVSRTTP YEPKRGLPLA 


VNPVS
Q28007 in FASTA format

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