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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-29.
TISSUE=Aorta, and Trachea;
PubMed=8006036 [NCBI, ExPASy, EBI, Israel, Japan]
Knaus H.-G.,
Folander K.,
Garcia-Calvo M.,
Garcia M.L.,
Kaczorowski G.J.,
Smith M.,
Swanson R.;
"Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.";
J. Biol. Chem. 269:17274-17278(1994).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford;
TISSUE=Uterus;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
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- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).
- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer (By similarity).
- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
- PTM: N-glycosylated (By similarity).
- SIMILARITY: Belongs to the KCNMB family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 191 AA [This is the length of the unprocessed precursor] |
Molecular weight: 21957 Da [This is the MW of the unprocessed precursor] |
CRC64: 111C15E4A2B6B545 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MGKKLVMAQR RGETRALCLG VAMVVGAVIT YYILGTTVLP LYQKSVWTQE STCHLIETNI
70 80 90 100 110 120
RDQEELEGKR VPQYPCLWVN VSSVGRWAVL YHTEDTRDQN HQCSYIPSSL DNYQVARADV
130 140 150 160 170 180
EKVRARFHEN QDFFCFSTTR ENETSVLYRR LYGPQSLLFS LFWPTFLLTG GLLIIVMVKI
190
NQSLSILAAQ R
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Q28067 in FASTA format |
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