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UniProtKB/Swiss-Prot entry Q29552

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name C11B1_PIG
Primary accession number Q29552
Secondary accession numbers None
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on November 1, 1997 (Sequence version 1)
Annotations were last modified on    September 2, 2008 (Entry version 45)
Name and origin of the protein
Protein name Cytochrome P450 11B1, mitochondrial [Precursor]
Synonyms EC 1.14.15.4
CYPXIB1
P450C11
Steroid 11-beta-hydroxylase
Gene name
Name: CYP11B1
From
Sus scrofa (Pig) [TaxID: 9823] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Adrenal gland;
DOI=10.1016/0960-0760(94)00167-K; PubMed=7696143 [NCBI, ExPASy, EBI, Israel, Japan]
Sun T., Zhao Y., Nonaka Y., Okamoto M.;
"Cloning and expression of cytochrome P450(11 beta) of porcine adrenal cortex.";
J. Steroid Biochem. Mol. Biol. 52:227-232(1995).
Comments
  • FUNCTION: Converts 11-deoxycorticosterone to corticosterone and 18-hydroxycorticosterone, and also produces aldosterone. May play a role in the biosynthesis of glucocorticoids as well as mineralocorticoids. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB.
  • CATALYTIC ACTIVITY: A steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O.
  • COFACTOR: Heme group (By similarity).
  • SUBCELLULAR LOCATION: Mitochondrion membrane.
  • SIMILARITY: Belongs to the cytochrome P450 family.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
D38590; BAA07600.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00189; 1SCC. [HSSP ENTRY / PDB]
ModBase Q29552.
Ontologies
GO
GO:0031966; Cellular component: mitochondrial membrane (inferred from electronic annotation from UniProtKB-SubCell).
QuickGo view.
Family and domain databases
InterPro IPR001128; Cyt_P450.
IPR002401; Cyt_P450_E_grp-I.
Graphical view of domain structure.
Gene3D G3DSA:1.10.630.10; Cyt_P450; 1.
PANTHER PTHR19383; Cyt_P450; 1.
Pfam PF00067; p450; 1.
Pfam graphical view of domain structure.
PRINTS PR00463; EP450I.
PR00385; P450.
PROSITE PS00086; CYTOCHROME_P450; 1.
BLOCKS Q29552.
Phylogenomic databases
HOVERGEN Q29552; -.
Other
ProtoNet Q29552.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Heme; Iron; Membrane; Metal-binding; Mitochondrion; Monooxygenase; Oxidoreductase; Steroidogenesis; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    24  24     Mitochondrion (By similarity). 
CHAIN   25   503  479     Cytochrome P450 11B1, mitochondrial. PRO_0000003602
METAL   450   450        Iron (heme axial ligand) (By similarity). 
Sequence information
Length: 503 AA [This is the length of the unprocessed precursor] Molecular weight: 57340 Da [This is the MW of the unprocessed precursor] CRC64: 4C40B1EEAAC49B05 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MAIWAKAEAW LAGPWLALNR ARTLGTRAVL APKGVLPFEA IPQFPGKKWM RVLQLWREQG 

        70         80         90        100        110        120 
FENNHLEMHQ TFQELGPIFR FDVGGRNMVL VMLPEDVERC QKVEGLHPQR DVPGPWLAYR 

       130        140        150        160        170        180 
HLRGHKCGVF LLNGPTWRLD RLQLNPGVLS LQAMQKFTPL VDGVARDFSQ ALRARVMQNA 

       190        200        210        220        230        240 
RGSLTLDIKP SIFRYTIEAS NLVLFGERLG LLAHQPNPES LDFIHALEVM FKSTVQLMFM 

       250        260        270        280        290        300 
PRSLSRWTST GTWKEHFEAW DCIFQYANKA IQRLYQELTL GHPWHYSGVV AELLTHANMT 

       310        320        330        340        350        360 
VDAIKANSID LTAGSVDTTA YPLLMTLFEL ARNPEVQQAL RQESLAAAAR ISENPQKAIT 

       370        380        390        400        410        420 
ELPLLRAALK ETLRLYPVGI FLDRCVTSDL VLQNYHIPAG TLVKVLLYSL GRNPAVFARP 

       430        440        450        460        470        480 
ERYHPQRWLD NQGSGTRFPH LAFGFGMRQC LGRRLAQVEM LLLLHHVLKN FLVETLVQED 

       490        500 
IKMIYRFIMT PSTLPLLTFR AIS
Q29552 in FASTA format

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