[1]	NUCLEOTIDE SEQUENCE [MRNA]. TISSUE=Liver; Atanasova S., von Ahsen N., Schlumbohm C., Wieland E., Oellerich M., Armstrong V.; "Free radical scavenging enzymes in Callithrix jacchus."; Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide (By similarity).
CATALYTIC ACTIVITY: 2 H₂O₂ = O₂ + 2 H₂O.
COFACTOR: Heme group (By similarity).
COFACTOR: NADP (By similarity).
SUBUNIT: Homotetramer (By similarity).
SUBCELLULAR LOCATION: Peroxisome (By similarity).
SIMILARITY: Belongs to the catalase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

DQ241811; ABB71446.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q2I6W4; 5-501.

ModBase

Q2I6W4.

Family and domain databases

InterPro

IPR002226; Catalase.
IPR011614; Catalase_N.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.180.10; Catalase_N; 1.

PANTHER

PTHR11465; Catalase; 1.

Pfam

PF00199; Catalase; 1.
Pfam graphical view of domain structure.

PRINTS

PR00067; CATALASE.

ProDom

PD000510; Catalase; 1.
[Domain structure / List of seq. sharing at least 1 domain]

PROSITE

PS00437; CATALASE_1; 1.
PS00438; CATALASE_2; 1.

BLOCKS

Q2I6W4.

Phylogenomic databases

HOVERGEN

Q2I6W4; -.

Other

ProtoNet

Q2I6W4.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Heme; Hydrogen peroxide; Iron; Metal-binding; NADP; Oxidoreductase; Peroxidase; Peroxisome; Phosphoprotein.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 527`	`526`	`Catalase.`	`PRO_0000266027`
`ACT_SITE`	`75 75`		`By similarity.`
`ACT_SITE`	`148 148`		`By similarity.`
`METAL`	`358 358`		`Iron (heme axial ligand) (By similarity).`
`MOD_RES`	`422 422`		`Phosphoserine (By similarity).`
`MOD_RES`	`517 517`		`Phosphoserine (By similarity).`

Sequence information

Length: 527 AA [This is the length of the unprocessed precursor]

Molecular weight: 59800 Da [This is the MW of the unprocessed precursor]

CRC64: 437902E9E785C1EA [This is a checksum on the sequence]

        10         20         30         40         50         60 
MADSRDPASD QMKHWKEQRA AQKADVLTTG AGNPVGDKLN VITAGPRGPL LVQDVVFTDE 

        70         80         90        100        110        120 
MAHFDRERIP ERVVHAKGAG AFGYFEVTHD ITKYSKAKVF EHIGKRTPIA VRFSTVAGES 

       130        140        150        160        170        180 
GSADTVRDPR GFAVKFYTED GNWDLVGNNT PIFFIRDPLL FPSFIHSQKR NPQTHLKHPD 

       190        200        210        220        230        240 
MVWDFWSLRP ESLHQVSFLF SDRGIPDGHR HMNGYGSHTF KLVNANGEAV YCKFHYKTDQ 

       250        260        270        280        290        300 
GIKNLSVEDA ARLSQEDPDY GLRDLFNAIA TGNYPSWTFY IQVMTFSQAE TFPFNPFDVT 

       310        320        330        340        350        360 
KIWPHKDYPL IPVGKLVLNR NPVNYFAEVE QIAFDPSNMP PGIEASPDKM LQGRLFSYPD 

       370        380        390        400        410        420 
THRHRLGPNY LQIPVNCPYR ARVANYQRDG PMCMQDNQGG APNYYPNSFG APEHQPSALE 

       430        440        450        460        470        480 
HSTRCSAEVQ RFNTANDDNV TQVRAFYVNV LNEEQRKRLC ENIAGHLKDA QLFIQKKAVK 

       490        500        510        520 
NFREVHNDYG TRIQALLDKY NAEKPKNAIH TFVQSGSHLA AREKANL

Q2I6W4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools