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UniProtKB/Swiss-Prot entry Q2JCX4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FOLD1_FRASC
Primary accession number Q2JCX4
Secondary accession numbers None
Integrated into Swiss-Prot on December 12, 2006
Sequence was last modified on March 7, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 21)
Name and origin of the protein
Protein name Bifunctional protein folD 1
Synonyms None
Includes Methylenetetrahydrofolate dehydrogenase
     (EC 1.5.1.5)
Methenyltetrahydrofolate cyclohydrolase
     (EC 3.5.4.9)
Gene name
Name: folD1
OrderedLocusNames: Francci3_1492
From
Frankia sp. (strain CcI3) [TaxID: 106370] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Frankineae; Frankiaceae; Frankia.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.5798407; PubMed=17151343 [NCBI, ExPASy, EBI, Israel, Japan]
Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N., Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A., Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P., Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C., Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J., Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F., Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C., Benson D.R.;
"Genome characteristics of facultatively symbiotic Frankia sp. strains reflect host range and host plant biogeography.";
Genome Res. 17:7-15(2007).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000249; ABD10868.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_480597.1; -.
3D structure databases
ModBase Q2JCX4.
Enzyme and pathway databases
BioCyc FSP106370:FRANCCI3_1492-MON; -.
Ontologies
GO
GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01576; -; 1.
PBIL [Tree]
InterPro IPR016040; NAD(P)-bd.
IPR000672; THF_DHase/CycOHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00763; THF_DHG_CYH; 1.
PF02882; THF_DHG_CYH_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00085; THFDHDRGNASE.
ProDom PD002300; THFDhg/Cyc_hydro; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00766; THF_DHG_CYH_1; FALSE_NEG.
PS00767; THF_DHG_CYH_2; FALSE_NEG.
BLOCKS Q2JCX4.
Genome annotation databases
GeneID 3903129; -.
GenomeReviews CP000249_GR; Francci3_1492.
KEGG fra:Francci3_1492; -.
Phylogenomic databases
HOGENOM Q2JCX4; -.
Genome annotation databases
CMR Q2JCX4; Francci3_1492.
Other
ProtoNet Q2JCX4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP; One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   276  276     Bifunctional protein folD 1. PRO_0000268354
Sequence information
Length: 276 AA [This is the length of the unprocessed precursor] Molecular weight: 27948 Da [This is the MW of the unprocessed precursor] CRC64: C29896B3F93B1C9A [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRMLDGRSMA AEIGRYVVDE AERLAAAGVT PTLAVVLPTA DPAAYSYAEI IERTAGKVGV 

        70         80         90        100        110        120 
HCVLHEPKGE PAAILDTIDT VAADPTVHGI IVQTPLPGGL TSREVGEHIP TAKDVDGMNP 

       130        140        150        160        170        180 
SSLGRLALGL PSFAPATAAA VVEILTRARI PMSGARVCVI GRGPVVGKPV SLLLLAEDAT 

       190        200        210        220        230        240 
VTICHSRTKG LVSIAHEADI IVSATGHPRL VGAGFVRPGA AVIDVGTVVT ETGQVGDVDA 

       250        260        270 
AAVSSVAGAL TPVPGGVGPV TTMLLLRNTI RAARAA 

Q2JCX4 in FASTA format

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