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UniProtKB/Swiss-Prot entry Q2KJH9

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name AL9A1_BOVIN
Primary accession number Q2KJH9
Secondary accession numbers None
Integrated into Swiss-Prot on May 30, 2006
Sequence was last modified on March 7, 2006 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 22)
Name and origin of the protein
Protein name 4-trimethylaminobutyraldehyde dehydrogenase
Synonyms TMABADH
EC 1.2.1.47
Aldehyde dehydrogenase family 9 member A1
EC 1.2.1.3
Gene name
Name: ALDH9A1
From
Bos taurus (Bovine) [TaxID: 9913] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Crossbred X Angus;
TISSUE=Ileum;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BC105335; AAI05336.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_001039888.1; -.
UniGene Bt.16137
3D structure databases
SMR Q2KJH9; 2-494.
ModBase Q2KJH9.
Ontologies
GO
GO:0004029; Molecular function: aldehyde dehydrogenase (NAD) activity (inferred from sequence or structural similarity from AgBase).
GO:0019145; Molecular function: aminobutyraldehyde dehydrogenase activity (inferred from sequence or structural similarity from AgBase).
GO:0006081; Biological process: aldehyde metabolic process (inferred from sequence or structural similarity from AgBase).
GO:0042136; Biological process: neurotransmitter biosynthetic process (inferred from sequence or structural similarity from AgBase).
GO:0055114; Biological process: oxidation reduction (inferred from sequence or structural similarity from AgBase).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q2KJH9.
Genome annotation databases
Ensembl ENSBTAG00000017852; Bos taurus. [Contig view]
GeneID 537539; -.
KEGG bta:537539; -.
Phylogenomic databases
HOVERGEN Q2KJH9; -.
Other
ProtoNet Q2KJH9.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acetylation; Cytoplasm; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   494  493     4-trimethylaminobutyraldehyde dehydrogenase. PRO_0000236270
NP_BIND   232   237  6     NAD (By similarity). 
ACT_SITE   254   254        Potential. 
ACT_SITE   288   288        Potential. 
MOD_RES   2     2        N-acetylserine (By similarity). 
Sequence information
Length: 494 AA [This is the length of the unprocessed precursor] Molecular weight: 53977 Da [This is the MW of the unprocessed precursor] CRC64: 74476EDC839F3241 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTGTFVVSQ PLNYRGGARV EPVDASGTEK AFEPASGRVI ATFTCSGEKE VNLAVQDAKA 

        70         80         90        100        110        120 
AFKIWSQKSG MERCRILLEA ARIIRERRDE IATMETINNG KSIFEARWDI DTSWQCLEYY 

       130        140        150        160        170        180 
AGLAGSMAGE HIQLPGGSFG YTRREPLGVC VGIGAWNYPF QIACWKSAPA LACGNAMVFK 

       190        200        210        220        230        240 
PSPFTPVSVL LLAEIYTEAG VPPGLFNVVQ GGAATGQFLC QHRDVAKVSF TGSVPTGSKI 

       250        260        270        280        290        300 
MEMSAKGIKP VTLELGGKSP LIIFSDCDMK NAVKGALMAN FLTQGEVCCN GTRVFVQKEI 

       310        320        330        340        350        360 
LDQFTEEVVK QTQRIKIGDP LLEDTRMGPL INRPHLERVL GFVKVAKEQG AKVLCGGDVF 

       370        380        390        400        410        420 
VPEDPKLKDG YYMRPCVLTN CRDDMTCVKE EIFGPVMSIL SFDTEAEVLE RANDTTFGLA 

       430        440        450        460        470        480 
AGVFTRDIQR AHRVVAELQA GMCFINNYNV SPVELPFGGY KKSGFGRENG RVTIEYYSQL 

       490 
KTVCVEMGDV ESAF
Q2KJH9 in FASTA format

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