[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. DOI=10.1371/journal.pone.0001120; PubMed=17971880 [NCBI, ExPASy, EBI, Israel, Japan] Herron-Olson L., Fitzgerald J.R., Musser J.M., Kapur V.; "Molecular correlates of host specialization in Staphylococcus aureus."; PLoS ONE 2:E1120-E1120(2007).

Comments

FUNCTION: May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer (By similarity).
CATALYTIC ACTIVITY: L-alanine + H₂O + NAD⁺ = pyruvate + NH₃ + NADH.
PATHWAY: Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1 .
SIMILARITY: Belongs to the AlaDH/PNT family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AJ938182; CAI80993.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_416780.1; -.

3D structure databases

ModBase

Q2YY66.

Enzyme and pathway databases

BioCyc

SAUR273036:SAB1304C-MON; -.

Family and domain databases

InterPro

IPR007698; Ala_DHase/PNT_C.
IPR008142; Ala_DHase/PNT_CS1.
IPR008143; Ala_DHase/PNT_CS2.
IPR007886; Ala_DHase/PNT_N.
IPR008141; Ala_DHase_PNT.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01262; AlaDh_PNT_C; 1.
PF05222; AlaDh_PNT_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00518; alaDH; 1.

PROSITE

PS00836; ALADH_PNT_1; FALSE_NEG.
PS00837; ALADH_PNT_2; 1.

BLOCKS

Q2YY66.

Genome annotation databases

GeneID

3794895; -.

GenomeReviews

AJ938182_GR; SAB1304c.

KEGG

sab:SAB1304c; -.

NMPDR

fig|273036.3.peg.969; -.

Phylogenomic databases

HOGENOM

Q2YY66; -.

Genome annotation databases

CMR

Q2YY66; SAB1304c.

Other

ProtoNet

Q2YY66.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 372`	`372`	`Alanine dehydrogenase 1.`	`PRO_0000287318`
`NP_BIND`	`170 200`	`31`	`NAD (By similarity).`
`ACT_SITE`	`94 94`		`Potential.`

Sequence information

Length: 372 AA [This is the length of the unprocessed precursor]

Molecular weight: 40145 Da [This is the MW of the unprocessed precursor]

CRC64: 91FD28D3AECA3130 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLVAVVKELK QGEGRVACTP ENVRKLTAAG HKVIVEKNAG IGSGFSNDMY EKEGAKIVTH 

        70         80         90        100        110        120 
EQAWEADLVI KVKEPHESEY QYFKKNQIIW GFLHLASSKE IVEKMQGVGV IAISGETIIK 

       130        140        150        160        170        180 
NGKAELLAPM SAIAGQRSAI MGAYYSEAQH GGQGTLVTGV HENVDIPGST YVIFGGGVAA 

       190        200        210        220        230        240 
TNAANVALGL NAKVIIIELN DDRIKYLEDM YAEKDVTVVK STPENLAEQI KKADVFISTI 

       250        260        270        280        290        300 
LIPGAKPPKL VTREMVKSMK KGSVLIDIAI DQGGTIETIR PTTISDPVYE EEGVIHYGVP 

       310        320        330        340        350        360 
NQPGAVPRTS TMALAQGNID YILEICDKGL EQAIKDNEAL SAGVNIYQGQ ETNQGLATSH 

       370 
DLDYKEILNV IE

Q2YY66 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools