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UniProtKB/Swiss-Prot entry Q31HQ4


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name FOLD1_THICR
Primary accession number Q31HQ4
Secondary accession numbers None
Integrated into Swiss-Prot on December 12, 2006
Sequence was last modified on December 12, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name Bifunctional protein folD 1
Synonyms None
Includes Methylenetetrahydrofolate dehydrogenase
     (EC 1.5.1.5)
Methenyltetrahydrofolate cyclohydrolase
     (EC 3.5.4.9)
Gene name
Name: folD1
OrderedLocusNames: Tcr_0723
From
Thiomicrospira crunogena (strain XCL-2) [TaxID: 317025] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales; Piscirickettsiaceae; Thiomicrospira.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1371/journal.pbio.0040383; PubMed=17105352 [NCBI, ExPASy, EBI, Israel, Japan]
Scott K.M., Sievert S.M., Abril F.N., Ball L.A., Barrett C.J., Blake R.A., Boller A.J., Chain P.S.G., Clark J.A., Davis C.R., Detter C., Do K.F., Dobrinski K.P., Faza B.I., Fitzpatrick K.A., Freyermuth S.K., Harmer T.L., Hauser L.J., Huegler M., Kerfeld C.A., Klotz M.G., Kong W.W., Land M., Lapidus A., Larimer F.W., Longo D.L., Lucas S., Malfatti S.A., Massey S.E., Martin D.D., McCuddin Z., Meyer F., Moore J.L., Ocampo L.H. Jr., Paul J.H., Paulsen I.T., Reep D.K., Ren Q., Ross R.L., Sato P.Y., Thomas P., Tinkham L.E., Zeruth G.T.;
"The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena XCL-2.";
PLoS Biol. 4:1-17(2006).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000109; ABB41319.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_390993.1; -.
3D structure databases
ModBase Q31HQ4.
Enzyme and pathway databases
BioCyc TCRU317025:TCR_0723-MON; -.
Ontologies
GO
GO:0004477; Molecular function: methenyltetrahydrofolate cyclohydrolase activity (inferred from electronic annotation from HAMAP).
GO:0004488; Molecular function: methylenetetrahydrofolate dehydrogenase (NADP+) activity (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01576; -; 1.
PBIL [Tree]
InterPro IPR000672; THF_DHase/CycOHase.
Graphical view of domain structure.
Pfam PF00763; THF_DHG_CYH; 1.
PF02882; THF_DHG_CYH_C; 1.
Pfam graphical view of domain structure.
PRINTS PR00085; THFDHDRGNASE.
ProDom PD002300; THFDhg/Cyc_hydro; 1.
[Domain structure / List of seq. sharing at least 1 domain]
PROSITE PS00766; THF_DHG_CYH_1; FALSE_NEG.
PS00767; THF_DHG_CYH_2; 1.
BLOCKS Q31HQ4.
Genome annotation databases
GeneID 3762098; -.
GenomeReviews CP000109_GR; Tcr_0723.
KEGG tcx:Tcr_0723; -.
NMPDR fig|317025.3.peg.1158; -.
Phylogenomic databases
HOGENOM Q31HQ4; -.
Genome annotation databases
CMR Q31HQ4; Tcr_0723.
Other
ProtoNet Q31HQ4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Hydrolase; Methionine biosynthesis; Multifunctional enzyme; NADP; One-carbon metabolism; Oxidoreductase; Purine biosynthesis.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   284  284     Bifunctional protein folD 1. PRO_0000268548
Sequence information
Length: 284 AA [This is the length of the unprocessed precursor] Molecular weight: 30154 Da [This is the MW of the unprocessed precursor] CRC64: 62A6C556F368CE87 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MSAQILDGKA IALELRDSIQ KEVEAQVANG KKPPGLAVIL VGEDPASQVY VKNKKIACEK 

        70         80         90        100        110        120 
AGFNDVSMVL PAETSQAELL AKIDELNTRD DVHGIIVQLP VPDHIDPEEI IERIDPKKDV 

       130        140        150        160        170        180 
DGFHPYNMGR LATRLPELAP CTPHGVMTML AKTGIPLRGL NAVVVGASNI VGVPMALELL 

       190        200        210        220        230        240 
NERATVTVCH SATKDLPQKV AEADLVVVGV GIPNMVKGDW IKDGAIVIDV GINRLDDGSL 

       250        260        270        280 
CGDVEYDVAK EKASWITPVP GGVGPMTIAT LLQNTLQAAY GVKA 

Q31HQ4 in FASTA format

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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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