[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Crossbred X Angus; TISSUE=Liver; NIH - Mammalian Gene Collection (MGC) project; Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation (By similarity).
CATALYTIC ACTIVITY: Inosine 5'-phosphate + NH₃ + NADP⁺ = guanosine 5'-phosphate + NADPH.
SIMILARITY: Belongs to the IMPDH/GMPR family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC109695; AAI09696.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001033208.1; -.

UniGene

Bt.76123

3D structure databases

SMR

Q32L93; 10-337.

ModBase

Q32L93.

Family and domain databases

InterPro

IPR013785; Aldolase_TIM.
IPR005993; GMP_reduct1.
IPR015875; IMP_DH/GMP_Rdtase_CS.
IPR001093; IMP_DHase_GMPRtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF00478; IMPDH; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000235; GMP_reductase; 1.

TIGRFAMs

TIGR01305; GMP_reduct_1; 1.

PROSITE

PS00487; IMP_DH_GMP_RED; 1.

BLOCKS

Q32L93.

Genome annotation databases

Ensembl

ENSBTAG00000002715; Bos taurus. [Contig view]

GeneID

515837; -.

KEGG

bta:515837; -.

Phylogenomic databases

HOVERGEN

Q32L93; -.

Other

ProtoNet

Q32L93.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Metal-binding; NADP; Oxidoreductase; Potassium.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 348`	`348`	`GMP reductase 2.`	`PRO_0000253472`
`NP_BIND`	`108 131`	`24`	`NADP (By similarity).`
`ACT_SITE`	`186 186`		`Thioimidate intermediate (By similarity).`
`METAL`	`181 181`		`Potassium (via carbonyl oxygen) (By similarity).`
`METAL`	`183 183`		`Potassium (via carbonyl oxygen) (By similarity).`
`BINDING`	`219 219`		`NADP (By similarity).`

Sequence information

Length: 348 AA [This is the length of the unprocessed precursor]

Molecular weight: 38033 Da [This is the MW of the unprocessed precursor]

CRC64: B4DA9AF8BC5474D2 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPHIDNDVKL DFKDVLLRPK RSTLKSRSEV DLTRSFAFRN SKQMYTGIPI IAANMDTVGT 

        70         80         90        100        110        120 
FEMAKVLCKF SLFTAVHKHY SLEQWKEFAS QNPDCLEHLA ASSGTGSSDF EQLEQILNAI 

       130        140        150        160        170        180 
PQVKYVCLDV ANGYSEHFVE FVKDVRKRFP EHTIMAGNVV TGEMVEELIL SGADIIKVGI 

       190        200        210        220        230        240 
GPGSVCTTRK KTGVGYPQLS AVMECADAAH GLKGHIISDG GCSCPGDVAK AFGAGADFVM 

       250        260        270        280        290        300 
LGGMLAGHSE SGGELIERNG RKYKLFYGMS SEMAMKKYAG GVAEYRASEG KTVEVPFKGD 

       310        320        330        340 
VEHTIRDIIG GIRSTCTYVG AAKQKELSRR TTFIRVTQQV KPIFSDES

Q32L93 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools