NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Saunders E.H., Schmutz J., Larimer F., Land M., Kyripides N., Anderson I., Richardson P.;
"Complete sequence of Pseudomonas fluorescens PfO-1.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate (By similarity).
CATALYTIC ACTIVITY: N-succinyl-L-glutamate 5-semialdehyde + NAD⁺ + H₂O = N-succinyl-L-glutamate + NADH.
PATHWAY: Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5 .
SIMILARITY: Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000094; ABA76019.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_350010.1; -.

3D structure databases

ModBase

Q3K885.

Enzyme and pathway databases

BioCyc

PFLU205922:PFL_4282-MON; -.

Ontologies

GO:0019544;	Biological process: arginine catabolic process to glutamate (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01174; -; 1.
PBIL [Tree]

InterPro

IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR017649; SuccinylGlu_semiald_DH_AstD.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.

PANTHER

PTHR11699; Aldehyde_dehyd; 1.

Pfam

PF00171; Aldedh; 1.
Pfam graphical view of domain structure.

PROSITE

PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.

BLOCKS

Q3K885.

Genome annotation databases

GeneID

3712894; -.

GenomeReviews

CP000094_GR; PflO1_4282.

KEGG

pfo:PflO1_4282; -.

Phylogenomic databases

HOGENOM

Q3K885; -.

Genome annotation databases

CMR

Q3K885; PflO1_4282.

Other

ProtoNet

Q3K885.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Arginine metabolism; Complete proteome; NAD; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 488`	`488`	`N-succinylglutamate 5-semialdehyde dehydrogenase.`	`PRO_0000262415`
`NP_BIND`	`221 226`	`6`	`NAD (By similarity).`
`ACT_SITE`	`244 244`		`By similarity.`
`ACT_SITE`	`278 278`		`By similarity.`

Sequence information

Length: 488 AA [This is the length of the unprocessed precursor]

Molecular weight: 51250 Da [This is the MW of the unprocessed precursor]

CRC64: 47B5200E919D5862 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MNSLYIAGEW LAGQGEAFQS LNPVTQQVLW SGEGATAAQV ESAVQAARQA FPGWARRTLE 

        70         80         90        100        110        120 
DRISVLEAFA AALKNHADEL ARTIGEETGK PLWEAATEVT SMVNKIAISV QSYRERTGEK 

       130        140        150        160        170        180 
SGPLGDATAV LRHKPHGVVA VFGPYNFPGH LPNGHIVPAL LAGNSVLFKP SELTPKVAEL 

       190        200        210        220        230        240 
TVKCWIEAGL PAGVLNLLQG ARETGIALAA NPGIDGLFFT GSSRTGNHLH QQFAGRPDKI 

       250        260        270        280        290        300 
LALEMGGNNP LVVDQVADID AAVYTIIQSA FISAGQRCTC ARRLLVPEGA WGDSLLKRLV 

       310        320        330        340        350        360 
EVSSTIEVGA FDQQPAPFMG SVVSLGAAKA LMDAQAHLLA NGAVSLLAMT QPQAQSALLT 

       370        380        390        400        410        420 
PGIVDVTAVA DRSDEELFGP LLQVIRYADF AAAIAEANDT AFGLAAGLLS DSEERYQQFW 

       430        440        450        460        470        480 
LESRAGIVNW NKQLTGAASS APFGGVGASG NHRASAYYAA DYCAYPVASL ETPSLVLPAA 


LTPGVKMA

Q3K885 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools