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UniProtKB/Swiss-Prot entry Q3MSM3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name SSDH_HYLLA
Primary accession number Q3MSM3
Secondary accession numbers None
Integrated into Swiss-Prot on November 22, 2005
Sequence was last modified on October 25, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 22)
Name and origin of the protein
Protein name Succinate-semialdehyde dehydrogenase, mitochondrial [Precursor]
Synonyms EC 1.2.1.24
NAD(+)-dependent succinic semialdehyde dehydrogenase
Aldehyde dehydrogenase family 5 member A1
Gene name
Name: ALDH5A1
From
Hylobates lar (Common gibbon) [TaxID: 9580] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hylobatidae; Hylobates.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
Blasi P., Palmerio F., Aiello A., Rocchi M., Malaspina P., Novelletto A.;
"Human succinic semialdehyde dehydrogenase variation in higher primates: intra and inter specific data.";
Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ891038; CAI69938.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
ModBase Q3MSM3.
Ontologies
GO
GO:0005625; Cellular component: soluble fraction (inferred from sequence or structural similarity from UniProtKB).
GO:0004777; Molecular function: succinate-semialdehyde dehydrogenase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0007417; Biological process: central nervous system development (inferred from sequence or structural similarity from UniProtKB).
GO:0009450; Biological process: gamma-aminobutyric acid catabolic process (inferred from sequence or structural similarity from UniProtKB).
GO:0055114; Biological process: oxidation reduction (inferred from sequence or structural similarity from UniProtKB).
GO:0051289; Biological process: protein homotetramerization (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.
Family and domain databases
InterPro IPR016160; Ald_DHase_CS.
IPR016162; Ald_DHase_N.
IPR015590; Aldehyde_DHase.
IPR010102; Succ_semiAld_DHase.
Graphical view of domain structure.
Gene3D G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
PANTHER PTHR11699; Aldehyde_dehyd; 1.
Pfam PF00171; Aldedh; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01780; SSADH; 1.
PROSITE PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PS00687; ALDEHYDE_DEHYDR_GLU; 1.
BLOCKS Q3MSM3.
Phylogenomic databases
HOVERGEN Q3MSM3; -.
Other
ProtoNet Q3MSM3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Mitochondrion; NAD; Oxidoreductase; Transit peptide.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
TRANSIT   1    47  47     Mitochondrion (Potential). 
CHAIN   48   535  488     Succinate-semialdehyde dehydrogenase, mitochondrial. PRO_0000042903
NP_BIND   284   289  6     NADP (By similarity). 
ACT_SITE   306   306        Proton acceptor (By similarity). 
ACT_SITE   340   340        Nucleophile (By similarity). 
SITE   205   205  1     Transition state stabilizer (By similarity). 
Sequence information
Length: 535 AA [This is the length of the unprocessed precursor] Molecular weight: 57112 Da [This is the MW of the unprocessed precursor] CRC64: 1D55DC672C6787B8 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MATCFWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGG LAGLSAALLR 

        70         80         90        100        110        120 
TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC SWREVSAKER 

       130        140        150        160        170        180 
SSLLRKWYNL MIQNKDDLAR IITAESGKPL KEAHGEILYS AFFLEWFSEE ARRVYGDIIY 

       190        200        210        220        230        240 
TPAKDRRALV LKQPIGVAAV ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL 

       250        260        270        280        290        300 
AELASQAGIP SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV 

       310        320        330        340        350        360 
KRVSMELGGL APFIVFDSAN VDQAVAGALA SKFRNTGQTC VCSNRFLVQR GIHDAFVKAF 

       370        380        390        400        410        420 
AEAMKKNLHV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV SKGATIVTGG KRHQLGKNFF 

       430        440        450        460        470        480 
EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD TEEEAIAIAN AADVGLAGYF YSQDPAQIWR 

       490        500        510        520        530 
VAEQLEVGMV GVNEGLISSV ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL
Q3MSM3 in FASTA format

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