[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Crossbred X Angus; TISSUE=Ileum; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases (By similarity).
CATALYTIC ACTIVITY: A 5,6,7,8-tetrahydropteridine + NAD(P)⁺ = a 6,7-dihydropteridine + NAD(P)H.
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC102193; AAI02194.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001069960.1; -.

UniGene

Bt.1735

3D structure databases

SMR

Q3T0Z7; 7-240.

ModBase

Q3T0Z7.

Ontologies

GO:0004155;	Molecular function: 6,7-dihydropteridine reductase activity (inferred from sequence or structural similarity from UniProtKB).
GO:0006729;	Biological process: tetrahydrobiopterin biosynthetic process (inferred from sequence or structural similarity from UniProtKB).
QuickGo view.

Family and domain databases

InterPro

IPR002198; DHase_sc/Rdtase_SDR.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

PROSITE

PS00061; ADH_SHORT; 1.

BLOCKS

Q3T0Z7.

Genome annotation databases

Ensembl

ENSBTAG00000003356; Bos taurus. [Contig view]

GeneID

618084; -.

KEGG

bta:618084; -.

Phylogenomic databases

HOVERGEN

Q3T0Z7; -.

Other

ProtoNet

Q3T0Z7.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Acetylation; NADP; Oxidoreductase; Tetrahydrobiopterin biosynthesis.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`INIT_MET`	`1 1`		`Removed (By similarity).`
`CHAIN`	`2 242`	`241`	`Dihydropteridine reductase.`	`PRO_0000284384`
`NP_BIND`	`12 36`	`25`	`NADP (By similarity).`
`ACT_SITE`	`148 148`		`Proton acceptor (By similarity).`
`MOD_RES`	`2 2`		`N-acetylalanine (By similarity).`

Sequence information

Length: 242 AA [This is the length of the unprocessed precursor]

Molecular weight: 25504 Da [This is the MW of the unprocessed precursor]

CRC64: C200631990475C7E [This is a checksum on the sequence]

        10         20         30         40         50         60 
MAAAAGEARR VLVYGGRGAL GSRCVQAFRA RNWWVASIDV QENEEASANV VVKMTDSFTE 

        70         80         90        100        110        120 
QADQVTAEVG KLLGTEKVDA ILCVAGGWAG GNAKSKSLFK NCDLMWKQSV WTSTISSHLA 

       130        140        150        160        170        180 
TKHLKEGGLL TLAGARAALD GTPGMIGYGM AKAAVHQLCQ SLAGKSSGLP PGAAAVALLP 

       190        200        210        220        230        240 
VTLDTPVNRK SMPEADFSSW TPLEFLVETF HDWITEKNRP SSGSLIQVVT TEGKTELTAA 


SP

Q3T0Z7 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools