[1]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. STRAIN=Hereford; TISSUE=Fetal liver; NIH - Mammalian Gene Collection (MGC) project; Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: (S)-2-hydroxy acid + O₂ = 2-oxo acid + H₂O₂.
COFACTOR: FMN (By similarity).
SUBUNIT: Homotetramer or homooctamer (By similarity).
SUBCELLULAR LOCATION: Peroxisome (By similarity).
SIMILARITY: Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.
SIMILARITY: Contains 1 FMN hydroxy acid dehydrogenase domain.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

BC103070; AAI03071.1; -; mRNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_001030243.1; -.

UniGene

Bt.46051

3D structure databases

SMR

Q3ZBW2; 2-350.

ModBase

Q3ZBW2.

Ontologies

GO:0003973;	Molecular function: (S)-2-hydroxy-acid oxidase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR013785; Aldolase_TIM.
IPR012133; Alpha_OHA_DHase_FMN.
IPR008259; FMN_hydac_DHase_AS.
IPR000262; FMN_OHA_DHase.
Graphical view of domain structure.

Gene3D

G3DSA:3.20.20.70; Aldolase_TIM; 1.

Pfam

PF01070; FMN_dh; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000138; Al-hdrx_acd_dh; 1.

PROSITE

PS00557; FMN_HYDROXY_ACID_DH_1; 1.
PS51349; FMN_HYDROXY_ACID_DH_2; 1.
PROSITE graphical view of domain structure (profiles).

BLOCKS

Q3ZBW2.

Genome annotation databases

Ensembl

ENSBTAG00000000123; Bos taurus. [Contig view]

GeneID

509481; -.

KEGG

bta:509481; -.

Phylogenomic databases

HOVERGEN

Q3ZBW2; -.

Other

ProtoNet

Q3ZBW2.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Flavoprotein; FMN; Oxidoreductase; Peroxisome.

Features

Feature table viewer

Feature aligner

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 353`	`353`	`Hydroxyacid oxidase 2.`	`PRO_0000285088`
`DOMAIN`	`1 353`	`353`	`FMN hydroxy acid dehydrogenase.`
`NP_BIND`	`279 303`	`25`	`FMN (By similarity).`
`MOTIF`	`351 353`	`3`	`Microbody targeting signal (Potential).`
`ACT_SITE`	`248 248`		`Proton acceptor (By similarity).`
`BINDING`	`106 106`		`FMN (By similarity).`
`BINDING`	`128 128`		`FMN (By similarity).`
`BINDING`	`130 130`		`Substrate (By similarity).`
`BINDING`	`156 156`		`FMN (By similarity).`
`BINDING`	`165 165`		`Substrate (By similarity).`
`BINDING`	`224 224`		`FMN (By similarity).`
`BINDING`	`251 251`		`Substrate (Potential).`

Sequence information

Length: 353 AA [This is the length of the unprocessed precursor]

Molecular weight: 39253 Da [This is the MW of the unprocessed precursor]

CRC64: E20D09034252F692 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MPLVCLTDFR EHAREHLSKS TWDFIEGGAD DCCTRDENMA AFKKIRLRPR YLKDVSKVDM 

        70         80         90        100        110        120 
RTTIQGAEIS APICIAPTGF HRLAWPDGEM STARAAQAAS ICYITSTYAS CSLEDIVAAA 

       130        140        150        160        170        180 
PRGLRWFQLY VHPNRQINKQ MIQKVESLGF KALVITVDVP KVGNRRNDIT NQVDLMKKLL 

       190        200        210        220        230        240 
LKDLGSPEMG NVMPYFQMSP IDPSICWEDL SWFQSMTRLP IILKGILTKE DAELAVKHNV 

       250        260        270        280        290        300 
HGIIVSNHGG RQLDEVPASI DALTEVVAAV KGKVEVYLDG GIRTGNDVLK ALALGAKCVF 

       310        320        330        340        350 
VGRPILWGLA YKGEHGVKEV LDILKNEFHT SMTLTGCRSV AEINQDLIQF SRL

Q3ZBW2 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools