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UniProtKB/Swiss-Prot entry Q3ZXL7

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_DEHSC
Primary accession number Q3ZXL7
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on September 27, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: cbdbA826
From
Dehalococcoides sp. (strain CBDB1) [TaxID: 255470] [HAMAP proteome]
Taxonomy Bacteria; Chloroflexi; Dehalococcoidetes; Dehalococcoides.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/nbt1131; PubMed=16116419 [NCBI, ExPASy, EBI, Israel, Japan]
Kube M., Beck A., Zinder S.H., Kuhl H., Reinhardt R., Adrian L.;
"Genome sequence of the chlorinated compound-respiring bacterium Dehalococcoides species strain CBDB1.";
Nat. Biotechnol. 23:1269-1273(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AJ965256; CAI82971.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_307887.1; -.
3D structure databases
ModBase Q3ZXL7.
Enzyme and pathway databases
BioCyc DSP255470:CBDBA826-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q3ZXL7.
Genome annotation databases
GeneID 3623070; -.
GenomeReviews AJ965256_GR; cbdbA826.
KEGG deh:cbdb_A826; -.
NMPDR fig|255470.3.peg.207; -.
Phylogenomic databases
HOGENOM Q3ZXL7; -.
Genome annotation databases
CMR Q3ZXL7; cbdbA826.
Other
ProtoNet Q3ZXL7.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   436  436     Histidinol dehydrogenase. PRO_0000135765
ACT_SITE   334   334        Proton acceptor (By similarity). 
ACT_SITE   335   335        Proton acceptor (By similarity). 
METAL   266   266        Zinc (By similarity). 
METAL   269   269        Zinc (By similarity). 
METAL   368   368        Zinc (By similarity). 
METAL   427   427        Zinc (By similarity). 
BINDING   136   136        NAD (By similarity). 
BINDING   198   198        NAD (By similarity). 
BINDING   221   221        NAD (By similarity). 
BINDING   244   244        Substrate (By similarity). 
BINDING   266   266        Substrate (By similarity). 
BINDING   269   269        Substrate (By similarity). 
BINDING   335   335        Substrate (By similarity). 
BINDING   368   368        Substrate (By similarity). 
BINDING   422   422        Substrate (By similarity). 
BINDING   427   427        Substrate (By similarity). 
Sequence information
Length: 436 AA [This is the length of the unprocessed precursor] Molecular weight: 46942 Da [This is the MW of the unprocessed precursor] CRC64: 4FE7208670BA48C6 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MKIIRGFAQA EKRLSRRDKA GFFLDETERT ELARRLGVDP EKAVNGIIAD VRKQGDEAVL 

        70         80         90        100        110        120 
GYTLKFDRAN LSKLEVGQPE IQQAASEIPA ELFEALQLAA SQIRAYHRFQ KEAVWKTAEI 

       130        140        150        160        170        180 
MQGKQLIRPL ERVGLYVPGG KAFYPSTVLM TAIPAREAGV KEIILVTPPG ANGKIPAPTL 

       190        200        210        220        230        240 
AAAQIAGVDR IFACGGAQAV AALAFGTKSI PKVDKICGPG NIFVTLAKKA VFGVVDIDGL 

       250        260        270        280        290        300 
QGPSEVLIVA DQYANAEYCA SDILAQAEHD ALASSILITT SEDLANRVND IVESKADTCS 

       310        320        330        340        350        360 
RRDIIKQSLR DNGLIAVVDN INEAIKLANM YAAEHLCLLV KDSEKYLTQI NHAGCIFYGE 

       370        380        390        400        410        420 
KASVVMGDYV AGPSHALPTS GTARFSSPLN ILDFVKYIDI VKVDKQDIAK LGQAAATIAK 

       430 
AEGLECHAEA VLKRLE
Q3ZXL7 in FASTA format

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