NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1074/jbc.270.31.18252; PubMed=7543100 [NCBI, ExPASy, EBI, Israel, Japan]
Chlumsky L.J., Zhang L., Jorns M.S.;
"Sequence analysis of sarcosine oxidase and nearby genes reveals homologies with key enzymes of folate one-carbon metabolism.";
J. Biol. Chem. 270:18252-18259(1995).

Comments

FUNCTION: Catalyzes the oxidative demethylation of sarcosine to yield glycine, hydrogen peroxide and 5,10-methylenetetrahydrofolate.
CATALYTIC ACTIVITY: Sarcosine + H₂O + O₂ = glycine + formaldehyde + H₂O₂.
SUBUNIT: Heterotetramer (alpha 100 kDa, beta 42 kDa, gamma 20 kDa, and delta 6 kDa).
SUBCELLULAR LOCATION: Cytoplasm.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

U23955; AAC43462.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

3D structure databases

SMR

Q46338; 10-199.

ModBase

Q46338.

Enzyme and pathway databases

BioCyc

MetaCyc:MON-8523; -.

Ontologies

GO:0008115;	Molecular function: sarcosine oxidase activity (inferred from electronic annotation from EC).
QuickGo view.

Family and domain databases

InterPro

IPR007375; SoxG.
IPR006280; SoxG_het.
Graphical view of domain structure.

Pfam

PF04268; SoxG; 1.
Pfam graphical view of domain structure.

TIGR01375; soxG; 1.

Other

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Cytoplasm; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 203`	`203`		`Sarcosine oxidase subunit gamma.`	`PRO_0000072051`

Sequence information

Length: 203 AA [This is the length of the unprocessed precursor]

Molecular weight: 21030 Da [This is the MW of the unprocessed precursor]

CRC64: 5A362FABFBCAED7F [This is a checksum on the sequence]

        10         20         30         40         50         60 
MASNTLIEST SVRRSPAEHL AEAMAQGSTA GTVQLREIAF ATQVGVRAVP GSGGFAALAE 

        70         80         90        100        110        120 
AVGTGLPQQV GVVAGSVEGT AVLWLGPDEF LAIAPEGAEL AAELVAALGD EPGQVLDLSA 

       130        140        150        160        170        180 
NRSVLELSGP AAPLVLRKSC PADLHPRAFG VNLAITTTLA NIPVLLWRTG EQSWYILPRA 

       190        200 
SFTEHTVHWL IDAMSEFASE PVA

Q46338 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools