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UniProtKB/Swiss-Prot entry Q46UA4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HGD_RALEJ
Primary accession number Q46UA4
Secondary accession numbers None
Integrated into Swiss-Prot on March 7, 2006
Sequence was last modified on March 7, 2006 (Sequence version 2)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name Homogentisate 1,2-dioxygenase
Synonyms EC 1.13.11.5
Homogentisicase
Homogentisate oxygenase
Homogentisic acid oxidase
Gene name
Name: hmgA
OrderedLocusNames: Reut_B3923
From
Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [TaxID: 264198] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Cupriavidus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
"Complete sequence of chromosome 2 of Ralstonia eutropha JMP134.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000091; AAZ63280.1; ALT_INIT; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_298124.1; -.
3D structure databases
ModBase Q46UA4.
Enzyme and pathway databases
BioCyc REUT264198:REUT_B3923-MON; -.
Ontologies
GO
GO:0004411; Molecular function: homogentisate 1,2-dioxygenase activity (inferred from electronic annotation from HAMAP).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from HAMAP).
GO:0006559; Biological process: L-phenylalanine catabolic process (inferred from electronic annotation from HAMAP).
GO:0006572; Biological process: tyrosine catabolic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00334; -; 1.
PBIL [Tree]
InterPro IPR005708; Homogentis_dOase.
Graphical view of domain structure.
PANTHER PTHR11056; Homogentis_dOase; 1.
Pfam PF04209; HgmA; 1.
Pfam graphical view of domain structure.
TIGRFAMs TIGR01015; hmgA; 1.
BLOCKS Q46UA4.
Genome annotation databases
GeneID 3614130; -.
GenomeReviews CP000091_GR; Reut_B3923.
KEGG reu:Reut_B3923; -.
NMPDR fig|264198.3.peg.4480; -.
Phylogenomic databases
HOGENOM Q46UA4; -.
Genome annotation databases
CMR Q46UA4; Reut_B3923.
Other
ProtoNet Q46UA4.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Dioxygenase; Iron; Metal-binding; Oxidoreductase; Phenylalanine catabolism; Tyrosine catabolism.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   439  439     Homogentisate 1,2-dioxygenase. PRO_0000225794
METAL   336   336        Iron (By similarity). 
METAL   342   342        Iron (By similarity). 
METAL   372   372        Iron (By similarity). 
Sequence information
Length: 439 AA [This is the length of the unprocessed precursor] Molecular weight: 48732 Da [This is the MW of the unprocessed precursor] CRC64: 293FAF36EFC3752D [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNLTHTQLAE HGYMSGFANE FATEALPGAL PVGQNSPQRA PYGLYAEQLS GTAFTAPRAH 

        70         80         90        100        110        120 
NRRSWLYRIR PGAVHKPFTL VEQSRFLSRF DEVPPSPNQM RWSPPAMPTT PTDFIDGIVT 

       130        140        150        160        170        180 
MAGNGGPDAM TGCGIHLYLA NQSMQDRFFY NADGEMLIVP QQGRVRFVTE MGRLDVEPQE 

       190        200        210        220        230        240 
IVVIPRGVRF RVELPDGEAR GYICENYGAL FKLPDLGVIG SNGLANPRDF MTPVAAYEDR 

       250        260        270        280        290        300 
EGDFELVAKF QGNLWRADIG HSPLDVVAWH GNFAPYKYDL RRFNTIGSIS FDHPDPSIFL 

       310        320        330        340        350        360 
VLQSPSDTPG VDTIDFVIFG PRWLAMENSF RPPWFHRNIA SEFMGLITGV YDAKADGFAP 

       370        380        390        400        410        420 
GGASLHNCMS GHGPDADTFA KATSADTSTP HHITDTMAFM FETPGVIRPT PYAARSASLQ 

       430 
QDYYTCWQGL KKHFNPNVR
Q46UA4 in FASTA format

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