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UniProtKB/Swiss-Prot entry Q46WL2

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX1_RALEJ
Primary accession number Q46WL2
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on September 13, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 22)
Name and origin of the protein
Protein name Histidinol dehydrogenase 1
Synonyms HDH 1
EC 1.1.1.23
Gene name
Name: hisD1
OrderedLocusNames: Reut_A3111
From
Ralstonia eutropha (strain JMP134) (Alcaligenes eutrophus) [TaxID: 264198] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Cupriavidus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Goltsman E., Martinez M., Schmutz J., Larimer F., Land M., Lykidis A., Richardson P.;
"Complete sequence of chromosome 1 of Ralstonia eutropha JMP134.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000090; AAZ62471.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_297315.1; -.
3D structure databases
ModBase Q46WL2.
Enzyme and pathway databases
BioCyc REUT264198:REUT_A3111-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
IPR002035; VWF_A.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
PR00453; VWFADOMAIN.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q46WL2.
Genome annotation databases
GeneID 3611937; -.
GenomeReviews CP000090_GR; Reut_A3111.
KEGG reu:Reut_A3111; -.
NMPDR fig|264198.3.peg.3551; -.
Phylogenomic databases
HOGENOM Q46WL2; -.
Genome annotation databases
CMR Q46WL2; Reut_A3111.
Other
ProtoNet Q46WL2.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   445  445     Histidinol dehydrogenase 1. PRO_0000135826
ACT_SITE   341   341        Proton acceptor (By similarity). 
ACT_SITE   342   342        Proton acceptor (By similarity). 
METAL   273   273        Zinc (By similarity). 
METAL   276   276        Zinc (By similarity). 
METAL   375   375        Zinc (By similarity). 
METAL   434   434        Zinc (By similarity). 
BINDING   144   144        NAD (By similarity). 
BINDING   205   205        NAD (By similarity). 
BINDING   228   228        NAD (By similarity). 
BINDING   251   251        Substrate (By similarity). 
BINDING   273   273        Substrate (By similarity). 
BINDING   276   276        Substrate (By similarity). 
BINDING   342   342        Substrate (By similarity). 
BINDING   375   375        Substrate (By similarity). 
BINDING   429   429        Substrate (By similarity). 
BINDING   434   434        Substrate (By similarity). 
Sequence information
Length: 445 AA [This is the length of the unprocessed precursor] Molecular weight: 47888 Da [This is the MW of the unprocessed precursor] CRC64: 4E3DF54A378ADE4B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MNATEMENVS IRRLDSSDPR FAQALREVLA FEAGEDEAID RAVAQILADV KDRGDAAVLE 

        70         80         90        100        110        120 
YTQRFDRVEA ASMGALEISQ SELEAALEDL EPKRRAALEA AAARVRAYHE KQKIECGSHS 

       130        140        150        160        170        180 
WEYTEADGTM LGQKVTPLDR VGIYVPGGKA AYPSSVLMNA IPARVAGVKE IIMVVPTPGG 

       190        200        210        220        230        240 
VRNELVLAAA QIAGVDRVFT IGGAQAVGAL AYGTATLPQV DKIVGPGNAY VAAAKRRVFG 

       250        260        270        280        290        300 
TVGIDMIAGP SEILVICDGT TDPDWVAMDL FSQAEHDELA QSILLCPDAD YIAQVEASIQ 

       310        320        330        340        350        360 
RQLDSMPRRE VIAASISGRG ALIKVRDMEE ACEIANAIAP EHLEISAENP RQWSEKIRHA 

       370        380        390        400        410        420 
GAIFLGRYTS ESLGDYCAGP NHVLPTSRTA RFSSPLGVYD FQKRSSLIEV SEGGAQMLGQ 

       430        440 
IAAELAYGEG LQAHARSAEY RFKRS
Q46WL2 in FASTA format

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