NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Di Bartolo G., Trong S., Kellar K., Schmutz J., Larimer F., Land M., Ivanova N., Richardson P.;
"Complete sequence of Dechloromonas aromatica RCB.";
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.

Comments

CATALYTIC ACTIVITY: Shikimate + NADP⁺ = 3-dehydroshikimate + NADPH.
PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and PEP: step 4/7 .
PATHWAY: Context: Aromatic amino acids biosynthesis .
SIMILARITY: Belongs to the shikimate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000089; AAZ48635.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_287105.1; -.

3D structure databases

ModBase

Q478U6.

Ontologies

GO:0004764;	Molecular function: shikimate 5-dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0009073;	Biological process: aromatic amino acid family biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00222; -; 1.
PBIL [Tree]

InterPro

IPR016040; NAD(P)-bd.
IPR011342; Quinate/shikimate_5-DHase.
IPR013708; Shikimate_DHase-bd_N.
IPR006151; Shikm_DHase/Glu-tRNA_Rdtase.
Graphical view of domain structure.

Gene3D

G3DSA:3.40.50.720; NAD(P)-bd; 1.

Pfam

PF01488; Shikimate_DH; 1.
PF08501; Shikimate_dh_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00507; aroE; 1.

BLOCKS

Q478U6.

Genome annotation databases

GeneID

3567695; -.

GenomeReviews

CP000089_GR; Daro_3907.

KEGG

dar:Daro_3907; -.

NMPDR

fig|159087.4.peg.2939; -.

Phylogenomic databases

HOGENOM

Q478U6; -.

Genome annotation databases

CMR

Q478U6; Daro_3907.

Other

ProtoNet

Q478U6.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Complete proteome; NADP; Oxidoreductase.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 274`	`274`	`Shikimate dehydrogenase.`	`PRO_0000325115`
`NP_BIND`	`127 131`	`5`	`NADP (By similarity).`

Sequence information

Length: 274 AA [This is the length of the unprocessed precursor]

Molecular weight: 28198 Da [This is the MW of the unprocessed precursor]

CRC64: 2040424C4EE1C405 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSDLYCVFGN PIAHSKSPAI HAAFAVQTAQ DLRYEARLAA LDGFGLAIAE FVAVGGKGAN 

        70         80         90        100        110        120 
VTVPFKEEAY RLATRLSDRA ARAGAVNTLV FDGPEVFGDN TDGAGLVRDI TNNLGFSLVG 

       130        140        150        160        170        180 
KRILLLGAGG ASRGVIAPLL AEKPASLIIA NRSADKAVAL AQAFADMAPL GGGSFAETAG 

       190        200        210        220        230        240 
KSFDLVINAT SASLSGASLP LPPGIFAPGS LAYDMMYGKG ETPFLTLARQ QGAARCADGL 

       250        260        270 
GMLVEQAAEA FFVWRGIRPG TAQVLAELRA KLVA

Q478U6 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools