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UniProtKB/Swiss-Prot entry Q492K3

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name HISX_BLOPB
Primary accession number Q492K3
Secondary accession numbers None
Integrated into Swiss-Prot on January 10, 2006
Sequence was last modified on September 13, 2005 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name Histidinol dehydrogenase
Synonyms HDH
EC 1.1.1.23
Gene name
Name: hisD
OrderedLocusNames: BPEN_478
From
Blochmannia pennsylvanicus (strain BPEN) [TaxID: 291272] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; ant endosymbionts; Candidatus Blochmannia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1101/gr.3771305; PubMed=16077009 [NCBI, ExPASy, EBI, Israel, Japan]
Degnan P.H., Lazarus A.B., Wernegreen J.J.;
"Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects.";
Genome Res. 15:1023-1033(2005).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000016; AAZ41094.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_277970.1; -.
3D structure databases
ModBase Q492K3.
Enzyme and pathway databases
BioCyc CBLO291272:BPEN_478-MON; -.
Ontologies
GO
GO:0004399; Molecular function: histidinol dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0000105; Biological process: histidine biosynthetic process (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_01024; -; 1.
PBIL [Tree]
InterPro IPR001692; Histidinol_DHase.
IPR012131; Hstdl_DHase_prok.
Graphical view of domain structure.
PANTHER PTHR21256:SF2; Hstdl_DH_prok; 1.
Pfam PF00815; Histidinol_dh; 1.
Pfam graphical view of domain structure.
PRINTS PR00083; HOLDHDRGNASE.
ProDom PD002680; Histidinol_dh; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00069; hisD; 1.
PROSITE PS00611; HISOL_DEHYDROGENASE; 1.
BLOCKS Q492K3.
Genome annotation databases
GeneID 3562985; -.
GenomeReviews CP000016_GR; BPEN_478.
KEGG bpn:BPEN_478; -.
Phylogenomic databases
HOGENOM Q492K3; -.
Genome annotation databases
CMR Q492K3; BPEN_478.
Other
ProtoNet Q492K3.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Complete proteome; Histidine biosynthesis; Metal-binding; NAD; Oxidoreductase; Zinc.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   443  443     Histidinol dehydrogenase. PRO_0000135735
ACT_SITE   329   329        Proton acceptor (By similarity). 
ACT_SITE   330   330        Proton acceptor (By similarity). 
METAL   262   262        Zinc (By similarity). 
METAL   265   265        Zinc (By similarity). 
METAL   363   363        Zinc (By similarity). 
METAL   422   422        Zinc (By similarity). 
BINDING   133   133        NAD (By similarity). 
BINDING   191   191        NAD (By similarity). 
BINDING   214   214        NAD (By similarity). 
BINDING   240   240        Substrate (By similarity). 
BINDING   262   262        Substrate (By similarity). 
BINDING   265   265        Substrate (By similarity). 
BINDING   330   330        Substrate (By similarity). 
BINDING   363   363        Substrate (By similarity). 
BINDING   417   417        Substrate (By similarity). 
BINDING   422   422        Substrate (By similarity). 
Sequence information
Length: 443 AA [This is the length of the unprocessed precursor] Molecular weight: 49150 Da [This is the MW of the unprocessed precursor] CRC64: E08D5771184EE9F4 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MISHEHPISI YWNDCSKSEQ KKLLTRPINN KLNDIYINVK NILTKVYNEG DRALFKFNFD 

        70         80         90        100        110        120 
FDNVQTTQLQ IPTEIIMNSG RNLSNEIKQA IHTAMTNITR FHQAQCYSEI IVETLPGVYC 

       130        140        150        160        170        180 
QQIIRPLNIV GLYVPGGTAP LLSTVMMLGV PARIAKCKRV ILCSPPPIPD VIIYTAQLCG 

       190        200        210        220        230        240 
IDEIYQIGGS QSIAAMGFGT ESIPKVDKIF GPGNIWVTEA KRQINLAPNG AAIDMLAGPS 

       250        260        270        280        290        300 
EILIIADNTA NPIFIAADLL SQSEHGPDSH AILITPYSCI AEKTKKELHK QLKILPRNDI 

       310        320        330        340        350        360 
VRNVLLNSRM IITNNLMECF SISNSYAPEH LIIQIENASD YLHYITNAGS IFLGNWSPET 

       370        380        390        400        410        420 
AGDYASGPNH VLPTYGRAVA TSGLGVIDFQ KRMSVQQLTQ NGLLQLSSTI TTLTQIEQLK 

       430        440 
AHEYAITHRI NYIKEQNEHS LLG
Q492K3 in FASTA format

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