FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AP008934; BAE18470.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_301415.1; -.

3D structure databases

ModBase

Q49XM5.

Enzyme and pathway databases

BioCyc

SSAP342451:SSP1325-MON; -.

Ontologies

GO:0004591;	Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred from electronic annotation from HAMAP).
GO:0030976;	Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from HAMAP).
GO:0006096;	Biological process: glycolysis (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_01169; -; 1.
PBIL [Tree]

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.

BLOCKS

Q49XM5.

Genome annotation databases

GeneID

3616663; -.

GenomeReviews

AP008934_GR; SSP1325.

KEGG

ssp:SSP1325; -.

NMPDR

fig|342451.4.peg.605; -.

Phylogenomic databases

HOGENOM

Q49XM5; -.

Genome annotation databases

CMR

Q49XM5; SSP1325.

Other

ProtoNet

Q49XM5.

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Glycolysis; Oxidoreductase; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 933`	`933`		`2-oxoglutarate dehydrogenase E1 component.`	`PRO_0000162185`

Sequence information

Length: 933 AA [This is the length of the unprocessed precursor]

Molecular weight: 105479 Da [This is the MW of the unprocessed precursor]

CRC64: 603C12A85D1562EB [This is a checksum on the sequence]

        10         20         30         40         50         60 
MSNESQVSEA PVNFGANLGY VLDLYDIYLD NPSAVPEDLQ VLFSTIKNGE ANIATNTEGQ 

        70         80         90        100        110        120 
SNVTKGDSTI KRVMRLIDNI RQYGHLLADI YPVNRPQREN VPKLNMEDFN LDQETLESIS 

       130        140        150        160        170        180 
AGIVSEHFKD IYDNAYEAIV RMEKRYKGPI AFEYTHINNN RERVWLKRRI ETPYKATLND 

       190        200        210        220        230        240 
NQKIELFKNL AHVEGFEKYL HKNFVGAKRF SIEGVDTLVP MLQQTLRIAS DEGIQNIQIG 

       250        260        270        280        290        300 
MAHRGRLNVL THVLEKPYEM MISEFMHIDP MKFLPEDGSL QLTSGWTGDV KYHLGGVKTT 

       310        320        330        340        350        360 
QSYGSEQRIS LANNPSHLEI VAPVVLGKTR ANQDTTDKPG AVTTEFKKSM PILIHGDAAY 

       370        380        390        400        410        420 
PGQGINFEAM NLGNLEGYST GGSLHIITNN RIGFTTEPED GRSTTYSSDV AKGYDVPIMH 

       430        440        450        460        470        480 
VNADNVEATI EAIEIAMAFR KEFNKDVVID LVGYRRYGHN EMDEPSITNP LQYYEIRKHE 

       490        500        510        520        530        540 
SVDILYGKQL VNENIISENQ MNQIFDDVQN TLRAAHDKID KNDKMDNPDM QKPDSLAEPI 

       550        560        570        580        590        600 
QTKDEEVSYE QLKEINDAML SYPSDFNVLK KLNKVLEKRR EPFESEDGLV DWAQAEQLAF 

       610        620        630        640        650        660 
ATITQNGRPI RLTGQDSERG TFSHRHAVLH DPDTGAQYVP LHNVPDQKAT FEVRNSPLSE 

       670        680        690        700        710        720 
AAVVGFEYGY NIQNKSCMTI WEAQYGDFSN MAQMIFDNFL FSSRAKWGER SGLTLFLPHS 

       730        740        750        760        770        780 
FEGQGPEHSS ARLERFLQLA GENNSTIVNL SSSSNYFHLL RAQAANLGTQ SMRPLVVMSP 

       790        800        810        820        830        840 
KSLLRNKTVA DPISKFTSGK FEPILPEAHD KASVKKVILA SGKMFIDLKE YLTKNPNKSI 

       850        860        870        880        890        900 
LLVAVERLYP FPADEIDALL SELPNLEHVA WVQEEPKNQG AWSFVYPYLK ELTTDKYDLS 

       910        920        930 
YHGRIQRSAP AEGDGEIHKL VQNMIIEQST NIN

Q49XM5 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools